Description

Efrapeptin B CAS NO 138145-53-6 is a potent, naturally occurring peptaibol antibiotic complex produced by the fungus Tolypocladium. This compound is highly valued for its specific inhibitory activity against mitochondrial F1F0-ATPase, making it a critical research tool in bioenergetics and cell biology. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies investigating mitochondrial function, ATP synthesis, and novel antimicrobial agents.

Application

• Biochemical Research: A specific and potent inhibitor of mitochondrial ATP synthase (F1F0-ATPase), used to study oxidative phosphorylation, cellular energetics, and ion transport.
• Cell Biology & Physiology: Employed in experiments to probe mitochondrial function, membrane potential, and the role of ATP in cellular processes like apoptosis and signal transduction.
• Antimicrobial Studies: Investigated for its intrinsic antifungal and antibacterial properties, serving as a lead compound or reference standard in the development of new antimicrobial agents.
• Insecticidal Research: Used in agricultural and entomological research due to its known toxicity against certain insect species, exploring potential biopesticide applications.
• Pharmaceutical Development: Serves as a reference standard in drug discovery pipelines targeting mitochondrial dysfunction, metabolic diseases, or infectious diseases.
• Enzyme Mechanism Studies: A crucial tool for enzymologists to elucidate the catalytic mechanism and structure-function relationships of the ATP synthase complex.

Basic Information

Product Name	Efrapeptin B
CAS No.	138145-53-6
Molecular Formula	C58H95N15O14
Molecular Weight	1210.5 g/mol
Synonyms	Efrapeptin B; Antibiotic LL-AF283B β; Efrapeptin B complex; ATPase inhibitor, Efrapeptin B; Peptaibol LL-AF283B β; Tolypocladium antibiotic B; F1F0-ATPase inhibitor (Efrapeptin B)
EINECS	Contact for details

Quality Control

Our Efrapeptin B is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and reliability for research applications. Each lot is characterized using advanced analytical techniques including HPLC for purity assessment and mass spectrometry for identity confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and other relevant parameters is provided with every shipment to support your research documentation and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Biological Activity (ATPase Inhibition)	IC50 provided on COA

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.