Description

Bisindolylmaleimide Vii is a potent and selective cell-permeable inhibitor of protein kinase C (PKC) isoforms. This high-purity biochemical tool is critical for research into intracellular signaling pathways, cellular proliferation, and apoptosis. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies engaged in kinase inhibitor development and signal transduction studies.

Application

• Biochemical Research: A key reagent for studying the role of Protein Kinase C (PKC) in various cellular processes and disease models.
• Pharmaceutical Development: Used as a reference standard and pharmacological tool in the discovery and validation of novel kinase-targeted therapeutics.
• Cell Signaling Studies: Employed to elucidate signal transduction cascades involving PKC in neuroscience, oncology, and immunology research.
• Academic Research: Essential for in vitro and ex vivo experiments in university and institutional laboratories focusing on molecular biology and pharmacology.
• High-Throughput Screening (HTS): Serves as a control compound in assay development and screening campaigns for PKC inhibitor identification.

Basic Information

Product Name	Bisindolylmaleimide Vii
CAS No.	137592-47-3
Molecular Formula	C₂₃H₂₀N₄O₂
Molecular Weight	384.43 g/mol
Synonyms	Bisindolylmaleimide VII; BIM-VII; 3-[1-[3-(Dimethylamino)propyl]-1H-indol-3-yl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione; Ro 31-8220; PKC Inhibitor VII; Protein Kinase C Inhibitor VII; 1H-Pyrrole-2,5-dione, 3-[1-[3-(dimethylamino)propyl]-1H-indol-3-yl]-4-(1H-indol-3-yl)-
EINECS	Contact for details

Quality Control

Our Bisindolylmaleimide Vii is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. The product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.