Description

Bisindolylmaleimide Ii CAS NO 137592-45-1 is a potent and selective cell-permeable inhibitor of protein kinase C (PKC). This compound is a critical research tool for studying intracellular signaling pathways and their role in cellular processes. It is primarily utilized by researchers and scientists in the pharmaceutical, biotechnology, and academic sectors for biochemical and pharmacological studies.

Application

• Biochemical Research: A key tool for investigating the role of Protein Kinase C (PKC) isoforms in signal transduction pathways.
• Pharmacological Studies: Used to study the effects of PKC inhibition on cell proliferation, differentiation, and apoptosis in various disease models.
• Neuroscience Research: Applied in studies of neuronal signaling, synaptic plasticity, and the mechanisms underlying neurological disorders.
• Oncology Research: Employed to explore the involvement of PKC in tumor progression and as a potential target for anticancer drug discovery.
• Cardiovascular Research: Utilized to examine PKC's function in cardiac hypertrophy, vascular tone, and heart failure.
• Inflammatory Disease Models: Used to assess the contribution of PKC to immune cell activation and inflammatory responses.

Basic Information

Product Name	Bisindolylmaleimide Ii
CAS No.	137592-45-1
Molecular Formula	C23H19N3O2
Molecular Weight	369.42 g/mol
Synonyms	Bisindolylmaleimide II; BIM II; GF 109203X; 2-[1-(3-Dimethylaminopropyl)-1H-indol-3-yl]-3-(1H-indol-3-yl)maleimide; 3-[1-[3-(Dimethylamino)propyl]-1H-indol-3-yl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione; PKC Inhibitor II; Go 6850
EINECS	Contact for details

Quality Control

Our Bisindolylmaleimide Ii is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for research applications. Each lot is analyzed using advanced techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	Yellow to orange solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.