Description

Bisindolylmaleimide Iii CAS NO 137592-43-9 is a potent and selective cell-permeable inhibitor of protein kinase C (PKC), specifically targeting the conventional and novel isoforms. This compound is a critical research tool for elucidating intracellular signaling pathways and studying the role of PKC in cellular processes such as proliferation, differentiation, and apoptosis. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in drug discovery and biochemical research.

Application

• Biochemical Research: A key tool for studying protein kinase C (PKC) signaling cascades and enzyme kinetics in vitro.
• Cell Biology Studies: Used to investigate the role of PKC in cellular functions including cell cycle regulation, gene expression, and secretion.
• Neuroscience Research: Applied in studies of neuronal signaling, synaptic plasticity, and the molecular mechanisms underlying neurological disorders.
• Oncology Research: Employed to explore PKC's involvement in tumor promotion, cancer cell survival, and metastasis for potential therapeutic target identification.
• Cardiovascular Research: Utilized to examine PKC's function in cardiac hypertrophy, vascular smooth muscle contraction, and endothelial cell signaling.
• Inflammatory Disease Models: Helps in understanding PKC-mediated pathways in immune cell activation and inflammatory responses.
• Drug Discovery Screening: Serves as a reference standard and pharmacological probe in high-throughput screening assays for novel kinase inhibitors.

Basic Information

Product Name	Bisindolylmaleimide Iii
CAS No.	137592-43-9
Molecular Formula	C₂₅H₂₁N₃O₂
Molecular Weight	395.45 g/mol
Synonyms	Bisindolylmaleimide III; BIM III; 3-[1-[3-(Dimethylamino)propyl]-1H-indol-3-yl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione; GF 109203X; Go 6850; PKC Inhibitor GF 109203X; Protein Kinase C Inhibitor, GF 109203X; 2,5-Pyrroledione, 3-[1-[3-(dimethylamino)propyl]-1H-indol-3-yl]-4-(1H-indol-3-yl)-1H-
EINECS	Contact for details

Quality Control

Our Bisindolylmaleimide Iii is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing including HPLC, NMR, and mass spectrometry for identity confirmation and purity verification. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting the exact specifications and test results.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. The product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Off-white to pale yellow solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.