Description

Platelet Activating Factor-16, Antagonist is a potent and selective synthetic inhibitor of platelet-activating factor (PAF) receptor activity. This compound is crucial for research into inflammatory pathways, thrombosis, and allergic responses, offering a high degree of specificity for mechanistic studies. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on developing novel therapeutics for cardiovascular, respiratory, and immunological disorders.

Application

• Pharmacological Research: Used as a key reference standard and tool compound for studying PAF-mediated signaling pathways in vitro and in vivo.
• Drug Discovery & Development: Serves as a lead compound or benchmark for developing new anti-inflammatory and anti-thrombotic agents targeting the PAF receptor.
• Biochemical Assays: Employed in high-throughput screening (HTS) and receptor binding assays to identify and characterize new PAF antagonists.
• Academic Studies: Facilitates fundamental research into the role of PAF in diseases such as asthma, sepsis, anaphylaxis, and atherosclerosis.
• Inflammation Models: Applied in experimental models to inhibit PAF-induced inflammatory responses, helping to validate therapeutic targets.

Basic Information

Product Name	Platelet Activating Factor-16, Antagonist
CAS No.	137566-83-7
Molecular Formula	C₂₆H₅₄N₇O₈P
Molecular Weight	615.73 g/mol
Synonyms	PAF-16 Antagonist; PAF Receptor Antagonist-16; Hexadecyl PAF Antagonist; 1-O-Hexadecyl-2-acetyl-sn-glycero-3-phospho(N,N,N-trimethyl)hexanolamine; BN 50730 (related analog class); CV-3988 (related analog class); WEB 2086 (related analog class); Platelet Activating Factor Inhibitor
EINECS	Contact for details

Quality Control

Our Platelet Activating Factor-16, Antagonist is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent controls for residual solvents and impurities. Certificates of Analysis (COA) with detailed chromatographic data are provided to ensure compliance with research-grade standards and support your regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, moisture-free environment. This hygroscopic and light-sensitive compound should be handled under inert atmosphere (argon or nitrogen) when opening to prevent degradation. Allow the vial to equilibrate to room temperature in a desiccator before use to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with reference structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines
Biological Activity (IC₅₀)	Reported value provided per batch

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.