Description

L-694,247 is a potent and selective non-peptide neurokinin-1 (NK1) receptor antagonist developed for research into central nervous system disorders, emesis control, and psychiatric conditions. It delivers high binding affinity and metabolic stability critical for preclinical pharmacological studies and drug discovery programs. This compound is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic neuroscience institutes engaged in target validation and mechanism-of-action studies. L-694,247 CAS NO 137403-12-4 is supplied under strict quality-controlled conditions to ensure batch-to-batch reproducibility and experimental reliability.

Application

• Preclinical research on neurokinin-1 receptor modulation in anxiety, depression, and stress-related disorders
• Investigation of antiemetic mechanisms in cisplatin-induced nausea and vomiting models
• Tool compound for positron emission tomography (PET) tracer development targeting NK1 receptors
• In vitro receptor binding assays (radioligand displacement) and functional G-protein signaling studies
• Pharmacokinetic and metabolism profiling in rodent and non-human primate models
• Lead optimization support in structure–activity relationship (SAR) campaigns for NK1 antagonists
• Validation of NK1 receptor expression and distribution in human tissue sections via autoradiography
• Control compound in high-throughput screening platforms for CNS-targeted therapeutics

Basic Information

Product Name	L-694,247
CAS No.	137403-12-4
Molecular Formula	C25H25ClN4O2
Molecular Weight	448.95 g/mol
Synonyms	L 694247; L-694247; L694247; (2R,3R)-2-(1H-Indol-3-yl)-3-(1-methyl-1H-benzo[d]imidazol-2-yl)-N-(4-chlorophenyl)propanamide; (2R,3R)-2-(1H-Indol-3-yl)-3-(1-methyl-1H-benzimidazol-2-yl)-N-(4-chlorophenyl)propanamide; MK-869 analog; CP-99,994 analog; Neurokinin-1 receptor antagonist L-694,247
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request. All batches of L-694,247 are tested for identity (IR, HPLC), assay (HPLC), related substances (HPLC), residual solvents (GC), and heavy metals (ICP-MS). The compound meets specifications aligned with research-grade pharmaceutical standards and is manufactured under ISO 9001-certified processes.

Storage

Preserve in a tightly closed container, protected from light. Store at 2–8 °C under inert atmosphere (argon or nitrogen) to prevent degradation. Due to its hygroscopic nature, maintain low-humidity conditions (<30% RH) and minimize exposure to ambient air during handling.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Single impurity ≤ 0.3%; Total impurities ≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C Class 3 limits
Water (Karl Fischer)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.