Description

5-Hydroxysaclofen is a potent and selective antagonist for the GABAB receptor subtype. This compound matters as a critical research tool for neuropharmacological studies, enabling the investigation of GABAergic signaling pathways and receptor function. It is primarily needed by pharmaceutical R&D teams, academic neuroscientists, and contract research organizations (CROs) engaged in central nervous system (CNS) drug discovery and basic neurochemical research.

Application

• Neuroscience Research: Used as a selective pharmacological tool to study the role of GABAB receptors in synaptic transmission and neural circuits.
• Drug Discovery Screening: Serves as a reference standard and active compound in high-throughput screening assays for identifying novel GABAB receptor modulators.
• Mechanistic Studies: Employed in in vitro and ex vivo experiments to elucidate the mechanisms of action of GABAergic drugs and their effects on neuronal excitability.
• Biochemical Assay Development: Utilized in the development and validation of receptor binding assays (e.g., radioligand binding) and functional cellular assays.
• Pharmacological Profiling: Acts as a control compound to determine the specificity and potency of new chemical entities targeting the GABAB receptor.
• Academic & Institutional Research: Supports fundamental research in universities and institutes focusing on anxiety, depression, spasticity, and addiction pathways.

Basic Information

Product Name	5-Hydroxysaclofen
CAS No.	137232-06-5
Molecular Formula	C10H12ClNO4S
Molecular Weight	277.72 g/mol
Synonyms	5-Hydroxy Saclofen; (3-Amino-2-(4-chlorophenyl)-2-hydroxypropyl)(hydroxy)sulfonyl-oxidanium; 2-Hydroxy-3-[(4-chlorophenyl)(hydroxy)sulfonylamino]propylammonium; GABAB receptor antagonist 5-Hydroxysaclofen; 4-Chloro-N-[2-hydroxy-3-(hydroxysulfamoyl)propyl]benzenesulfonamide
EINECS	Contact for details

Quality Control

Our 5-Hydroxysaclofen is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity, identity, and consistency suitable for advanced research applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay results, and impurity profiles is provided with every shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤2.0%
Solubility	Soluble in DMSO, Methanol; sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.