Description

Plitidepsin is a potent, naturally occurring cyclic depsipeptide originally isolated from the marine tunicate *Aplidium albicans*. This compound is of significant interest due to its unique mechanism of action targeting the eukaryotic translation elongation factor 1A (eEF1A). It is supplied as a high-purity reference standard and active pharmaceutical ingredient (API) for research and development. Key target industries include pharmaceutical R&D, oncology research, and biotechnology, where it is utilized in preclinical studies, mechanism of action research, and as a lead compound for novel therapeutic development.

Application

• Pharmaceutical Reference Standard: Serves as a primary standard for analytical method development, validation, and quality control in API and finished product manufacturing.
• Oncology Research: Used in in vitro and in vivo studies to investigate its antitumor activity, particularly against multiple myeloma and other hematological malignancies.
• Mechanistic Studies: A critical tool for studying protein synthesis inhibition, apoptosis induction, and the role of eEF1A in cancer cell proliferation.
• Drug Discovery & Development: Acts as a lead compound for the synthesis of novel analogs and the development of new anticancer therapeutics.
• Biochemical Research: Employed in assays to understand intracellular trafficking and the specific interactions between depsipeptides and cellular targets.

Basic Information

Product Name	Plitidepsin
CAS No.	137219-37-5
Molecular Formula	C₆₃H₉₅N₇O₁₅
Molecular Weight	1182.46 g/mol
Synonyms	Aplidin; Dehydrodidemnin B; Didemnin B, 2,3-didehydro-; (3S,6S,9S,12S,15S,18S,21S,24S,30S,33S)-30-[(2S)-1-Hydroxy-4-methyl-1-oxopentan-2-yl]-6,9,12,18,21,24-hexamethyl-3,15-bis(1-methylethyl)-1,4,7,10,13,16,19,22,25,28,31-undecaoxo-33-(phenylmethyl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone; NSC-687528; PharmaMar Compound PM00104
EINECS	Contact for details

Quality Control

Our Plitidepsin is manufactured under strict quality systems to ensure the highest standards of purity and consistency, suitable for research and development applications. Each batch is subjected to comprehensive analytical testing including HPLC for purity and identity confirmation. A detailed Certificate of Analysis (COA) is provided, documenting critical quality attributes. While produced with research-grade focus, our processes adhere to principles of GMP for reliable and traceable supply.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. Due to its hygroscopic nature, the container must be sealed under an inert atmosphere (e.g., nitrogen or argon) after each use to prevent moisture absorption and degradation. Allow the sealed vial to equilibrate to room temperature before opening to minimize condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (Mass Spectrometry)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (Karl Fischer)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	< 20 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.