Description

ω-Agatoxin Iii is a highly specific and potent peptide neurotoxin that selectively blocks P/Q-type voltage-gated calcium channels. This precise mechanism of action makes it an invaluable research tool for studying neuronal signaling, synaptic transmission, and calcium channel physiology. It is essential for neuroscientists, pharmacologists, and biochemists in academic, pharmaceutical, and biotechnology sectors conducting fundamental neurological research and drug discovery programs.

Application

• Neuroscience Research: A critical tool for the selective inhibition of P/Q-type calcium channels (Cav2.1) in electrophysiological studies to understand their role in neurotransmitter release and neuronal excitability.
• Pharmacological Studies: Used to characterize and differentiate calcium channel subtypes in cell-based assays and tissue preparations, aiding in the development of novel therapeutics for neurological disorders.
• Synaptic Physiology: Employed to investigate the precise mechanisms of synaptic vesicle fusion and the calcium-dependence of neurotransmitter release at central nervous system synapses.
• Channelopathy Modeling: Facilitates the creation of experimental models to study diseases linked to P/Q-type channel dysfunction, such as certain forms of migraine, ataxia, and epilepsy.
• Biochemical Assay Development: Serves as a high-affinity ligand in binding assays and for the purification and isolation of specific calcium channel complexes.
• Toxicology & Venom Research: Used in comparative studies of spider venoms and the structure-activity relationships of peptide toxins.

Basic Information

Item	Detail
Product Name	ω-Agatoxin Iii
CAS No.	137094-82-7
Molecular Formula	C185H274N52O55S7
Molecular Weight	~4280.9 g/mol
Synonyms	ω-Agatoxin III; ω-Aga-III; Agatoxin III; ω-Agatoxin III; P/Q-type calcium channel blocker; Voltage-gated calcium channel inhibitor; Synthetic ω-agatoxin III; American funnel-web spider toxin analog; Cav2.1 channel antagonist
EINECS	Contact for details

Quality Control

Every batch of ω-Agatoxin Iii is produced and analyzed under stringent conditions to ensure the highest standards of purity and biological activity for research applications. Our quality assurance includes comprehensive testing for identity, purity, and potency. A Certificate of Analysis (COA) detailing lot-specific results from HPLC, MS, and functional activity assays is provided with each shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature in a desiccator before opening to prevent condensation and hydrolysis. Aliquot reconstituted solutions to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Biological Activity (IC50)	Specified per batch (typically low nM range for P/Q-type channels)
Solubility	Soluble in aqueous buffers
Endotoxin Level	< 1.0 EU/μg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.