Description

Hydrocodone-D3 is a stable isotope-labeled internal standard, specifically the deuterated analog of the opioid analgesic hydrocodone. This compound is essential for ensuring the accuracy and reliability of quantitative analysis in complex biological matrices. It is primarily utilized by analytical laboratories and pharmaceutical R&D departments engaged in method development, forensic toxicology, and pharmacokinetic studies.

Application

• Quantitative Internal Standard for the precise measurement of hydrocodone and related metabolites in bioanalytical methods using LC-MS/MS or GC-MS.
• Method Development & Validation in pharmaceutical research to establish robust, accurate, and reproducible analytical procedures.
• Forensic Toxicology & Clinical Testing for the unambiguous identification and quantification of hydrocodone in urine, blood, or plasma samples.
• Pharmacokinetic & Metabolism Studies to track drug absorption, distribution, metabolism, and excretion with high specificity.
• Quality Control & Reference Material in the manufacturing and testing of pharmaceutical products containing hydrocodone.
• Research into Drug-Drug Interactions and metabolic pathways involving the cytochrome P450 enzyme system.

Basic Information

Product Name	Hydrocodone-D3
CAS No.	136765-36-1
Molecular Formula	C18H18D3NO3
Molecular Weight	302.39 g/mol
Synonyms	4,5α-Epoxy-3-methoxy-17-methylmorphinan-6-one-D3; Dihydrocodeinone-D3; (5α)-4,5-Epoxy-3-methoxy-17-methylmorphinan-6-one-D3; Norcodeine-D3 derivative; Deuterated Hydrocodone; Hydrocodone-d3; Hydrocodone (methyl-d3); Internal Standard Hydrocodone-D3
EINECS	Contact for details

Quality Control

Our Hydrocodone-D3 is manufactured under strict quality systems to ensure the high purity and isotopic enrichment required for analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as chemical purity, isotopic purity (D-enrichment), and absence of interfering substances. We adhere to relevant industry standards for reference materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity	≥ 99.0 atom % D
Chemical Purity	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.