Description

L-Cystine-1,1μ-13C2 CAS NO 136743-62-9 is a stable isotope-labeled analog of the essential amino acid L-Cystine, specifically labeled with two carbon-13 atoms at the 1 and 1' positions. This high-purity compound is critical for advanced research and development, providing a non-radioactive tracer for precise metabolic and pharmacokinetic studies. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and diagnostic manufacturers requiring exacting standards for mass spectrometry and NMR analysis.

Application

• Biomedical Research Tracer: Used as an internal standard in quantitative mass spectrometry (LC-MS/MS, GC-MS) for accurate measurement of L-Cystine and related metabolites in biological samples.
• Metabolic Pathway Analysis: Enables detailed tracking of sulfur-containing amino acid metabolism, protein synthesis, and glutathione production in cell culture and in vivo studies.
• Pharmaceutical Development: Supports drug metabolism and pharmacokinetics (DMPK) studies for new drug candidates targeting conditions related to cysteine/cystine balance.
• Clinical Diagnostics: Serves as a critical component in the development and calibration of advanced diagnostic assays for metabolic disorders like cystinuria.
• Nutritional Science Research: Facilitates studies on protein digestion, amino acid absorption, and the biochemical impact of dietary supplements.
• Stable Isotope Labeling: Used in the synthesis of more complex isotopically labeled peptides, proteins, and probes for structural biology and proteomics.

Basic Information

Product Name	L-Cystine-1,1μ-13C2
CAS No.	136743-62-9
Molecular Formula	C413C2H12N2O4S2
Molecular Weight	242.29 g/mol (for 13C2 labeled form)
Synonyms	(2R,2'R)-3,3'-Dithiobis(2-aminopropanoic-1-13C) acid; L-Cystine-1,1'-13C2; [1,1'-13C2]-L-Cystine; Isotopically Labeled L-Cystine; Cystine-13C2; (R,R)-Cystine-1,1'-13C2; 3,3'-Dithiobis[2-aminopropionic-1-13C] acid
EINECS	Contact for details

Quality Control

Our L-Cystine-1,1μ-13C2 is manufactured under strict quality systems to ensure exceptional isotopic and chemical purity for sensitive analytical applications. Each batch is characterized by advanced techniques including NMR, HPLC, and mass spectrometry to confirm isotopic enrichment, chemical identity, and purity. Comprehensive Certificates of Analysis (COA) are provided, detailing assay, isotopic purity, chiral purity, and related substance profiles. We adhere to cGMP principles where applicable to support regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent exposure to atmospheric moisture. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure and labeling pattern
Assay (HPLC)	≥ 98.0%
Isotopic Purity (13C)	≥ 99 atom % 13C
Isotopic Enrichment (MS)	≥ 99% 13C2
Optical Rotation	-215° to -225° (c=1 in 1N HCl)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.