Description

Glucoallosamidin B CAS NO 136236-42-5 is a potent and specific inhibitor of the enzyme glucosidase II, which plays a critical role in the N-linked glycoprotein processing pathway. This compound is a vital research tool for studying protein folding, quality control within the endoplasmic reticulum, and the broader mechanisms of glycobiology. It is primarily utilized by researchers in pharmaceutical development, academic biochemistry, and biotechnology sectors for investigating metabolic disorders, viral infectivity, and cancer biology.

Application

• Biochemical Research: A key tool for studying N-linked oligosaccharide processing and endoplasmic reticulum-associated degradation (ERAD).
• Enzyme Inhibition Studies: Used to specifically inhibit glucosidase II activity in vitro and in cell-based assays to elucidate its biological function.
• Glycobiology & Cell Biology: Investigates the role of protein glycosylation in cell signaling, protein trafficking, and immune response.
• Drug Discovery & Development: Serves as a reference compound or lead structure for developing novel therapeutics targeting glycosidases for diseases like diabetes, viral infections, and cancer.
• Academic & Institutional Labs: Essential for fundamental research in molecular biology, biochemistry, and structural biology.
• Diagnostic Reagent Development: Potential use in the formulation of enzyme assay kits and diagnostic tools for metabolic conditions.

Basic Information

Product Name	Glucoallosamidin B
CAS No.	136236-42-5
Molecular Formula	C17H30N2O10
Molecular Weight	422.43 g/mol
Synonyms	Glucoallosamidin B; Allosamidin derivative; Glucosidase II Inhibitor; N,N'-Bis(β-D-glucopyranosyl)-1,4-dideoxy-1,4-imino-D-allitol; 1,4-Dideoxy-1,4-imino-N,N'-bis(β-D-glucopyranosyl)-D-allitol; GlcNAcstatin B; α-Glucosidase II Inhibitor
EINECS	Contact for details

Quality Control

Our Glucoallosamidin B is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity for research applications. Each lot is characterized using advanced analytical techniques including HPLC, NMR, and MS to confirm identity and potency. A comprehensive Certificate of Analysis (COA) detailing purity, assay results, and analytical data is provided with every shipment to support your research and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Assay	≥ 98% (on dried basis)
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Biological Activity (IC50)	Reported per COA

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.