Description

Go 6976 CAS NO 136194-77-9 is a potent and selective cell-permeable inhibitor of protein kinase C (PKC), specifically targeting the classical PKCα and PKCβ isoforms. This compound is a critical research tool for elucidating the role of PKC signaling pathways in cellular processes such as proliferation, differentiation, and apoptosis. It is primarily utilized by researchers and scientists in the fields of biochemical research, pharmaceutical development, and cell biology for target validation and mechanistic studies.

Application

• Biochemical Research: A key tool for studying the structure, function, and inhibition mechanisms of protein kinase C isoforms in vitro.
• Pharmaceutical R&D: Used in high-throughput screening and target validation for developing novel therapeutics targeting PKC-related diseases, including cancer and inflammatory disorders.
• Cell Signaling Studies: Employed to dissect PKC-mediated signal transduction pathways and their impact on cell cycle regulation and programmed cell death.
• Academic Research: Fundamental reagent for universities and research institutes investigating the role of PKC in neuroscience, cardiology, and immunology.
• Preclinical Studies: Utilized in animal models to investigate the therapeutic potential of PKC inhibition for various pathological conditions.

Basic Information

Product Name	Go 6976
CAS No.	136194-77-9
Molecular Formula	C₂₆H₂₇N₅O₂
Molecular Weight	441.52 g/mol
Synonyms	Go6976; 12-(2-Cyanoethyl)-6,7,12,13-tetrahydro-13-methyl-5-oxo-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole; 5H-Indolo[2,3-a]pyrrolo[3,4-c]carbazole-5-one, 6,7,12,13-tetrahydro-13-methyl-12-(2-cyanoethyl)-; PKC Inhibitor Go 6976; Protein Kinase C Inhibitor Go 6976; 3-[1-[3-(Dimethylamino)propyl]-5-methoxy-1H-indol-3-yl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione (Note: This is a common misassignment; the correct structure is as listed above).
EINECS	Contact for details

Quality Control

Our Go 6976 is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity determination and structural confirmation via spectroscopic methods. Certificates of Analysis (COA) detailing all specifications and test results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a desiccated environment to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	Yellow to light brown solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.