Description

n-(3-(4-Azido-3-Iodophenyl)Propionamide)-6-Aminoethylcarbamylforskolin is a high-purity, photoactivatable forskolin derivative designed for advanced biochemical and pharmacological research. This compound is engineered for precise covalent cross-linking and labeling studies, offering researchers a powerful tool for probing adenylate cyclase activity and cAMP signaling pathways. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies specializing in signal transduction, target identification, and molecular probe development.

Application

• Photoaffinity Labeling: Acts as a critical probe for covalently labeling and identifying adenylate cyclase binding sites and associated proteins in complex biological systems.
• Signal Transduction Research: Used to study cAMP-dependent pathways, G-protein coupled receptor (GPCR) function, and cellular second messenger systems with high specificity.
• Molecular Pharmacology: Enables the investigation of drug-target interactions and the mechanism of action of forskolin analogs through irreversible binding.
• Bioconjugation & Probe Development: Serves as a key intermediate for synthesizing more complex molecular probes and conjugates for fluorescence or affinity-based assays.
• Enzyme Activity Studies: Facilitates the detailed kinetic and structural analysis of adenylate cyclase activation and regulation.

Basic Information

Product Name	n-(3-(4-Azido-3-Iodophenyl)Propionamide)-6-Aminoethylcarbamylforskolin
CAS No.	136103-68-9
Molecular Formula	C31H36IN7O5
Molecular Weight	737.56 g/mol
Synonyms	6-[2-[(E)-3-(4-Azido-3-iodophenyl)prop-2-enoylamino]ethylcarbamoyl]forskolin; 6-AEC-Forskolin Azido-Iodo Derivative; 6-(2-Aminoethylcarbamoyl)forskolin 3-(4-Azido-3-iodocinnamamido) Derivative; Photoactivatable Forskolin Iodoazide; cAMP Pathway Photoaffinity Probe; 7β-Acetoxy-8,13-epoxy-1α,6β,9α-trihydroxy-labd-14-en-11-one 6-(2-((E)-3-(4-Azido-3-iodophenyl)acrylamido)ethylcarbamate); Forskolin-6-AEC-APIP
EINECS	Contact for details

Quality Control

This high-value research chemical is produced under stringent quality protocols to ensure batch-to-batch consistency and reliability. Each lot is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry to confirm identity, purity, and functional integrity. A comprehensive Certificate of Analysis (COA) detailing purity, spectral data, and storage recommendations is provided with every shipment to support critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This compound is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, keep under an inert atmosphere. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.