Description

Heparin Disaccharide III-A, Sodium Salt is a well-defined, low molecular weight oligosaccharide derived from the enzymatic or chemical depolymerization of heparin. This compound serves as a critical reference standard and biochemical tool for research into heparin's structure-activity relationships and its interactions with proteins. It is essential for scientists and quality control professionals in the pharmaceutical and biotechnology sectors who require high-purity materials for analytical method development, bioactivity studies, and regulatory submissions.

Application

• Pharmaceutical Reference Standard: Used as a primary standard for the identification, assay, and impurity profiling of heparin and low molecular weight heparin (LMWH) products.
• Biochemical Research: Critical for studying the specific interactions between heparin/heparan sulfate and growth factors, cytokines, and enzymes (e.g., antithrombin III).
• Enzyme Substrate/Inhibitor Studies: Employed as a defined substrate for heparinases and sulfatases or as an inhibitor in kinetic assays.
• Analytical Method Development: Serves as a calibration standard in advanced chromatographic (HPLC, CE) and mass spectrometric (LC-MS) techniques for glycan analysis.
• Quality Control & Assurance: Integral to in-process testing and final release testing of heparin-based APIs to ensure batch-to-batch consistency and compliance.
• Diagnostic Reagent Component: Used in the formulation of diagnostic kits and assays that measure heparin levels or related enzymatic activities.

Basic Information

Product Name	Heparin Disaccharide III-A, Sodium Salt
CAS No.	136098-11-8
Molecular Formula	C14H21NO14S2 • xNa
Molecular Weight	Contact for details
Synonyms	δUA-GlcNS,6S; 2-O-Sulfo-α-L-iduronic acid-1→4-2-deoxy-6-O-sulfo-2-sulfamino-α-D-glucopyranose, Sodium Salt; Heparin Disaccharide II-A (deprecated); Unsaturated Heparin Disaccharide; IdoA2S-GlcNS6S; Sodium (2S,3S,4R,5R,6R)-6-[(1S,2R,4S,5R)-4,5-dihydroxy-2-(sulfooxy)cyclopent-1-en-1-yl]oxy-3,4-dihydroxy-5-sulfooxy-2-(sulfonamido)oxane-2-carboxylate; Heparin-derived disaccharide.
EINECS	Contact for details

Quality Control

Our Heparin Disaccharide III-A, Sodium Salt is manufactured under strict quality systems. Each batch is subjected to a comprehensive suite of analytical tests, including HPLC for purity and identity confirmation and NMR for structural verification. We provide full traceability and a detailed Certificate of Analysis (COA) with each shipment, ensuring the material meets the stringent requirements for use as a pharmaceutical reference standard and in critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This material is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Specific Optical Rotation	Contact for details
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.