Description

Heparin Disaccharide I-A Sodium is a well-defined, low molecular weight oligosaccharide derivative of heparin, a critical glycosaminoglycan. This compound serves as a fundamental building block and a vital reference standard for research into heparin's complex structure, biological activity, and metabolism. It is essential for scientists and quality control professionals in the pharmaceutical and biotechnology sectors who require precise tools for analytical method development, enzymatic studies, and the characterization of heparin-based products.

Application

• Analytical Reference Standard: Used as a primary standard in High-Performance Liquid Chromatography (HPLC), Capillary Electrophoresis (CE), and Mass Spectrometry (MS) for the identification and quantification of heparin and its derivatives.
• Enzymology Research: Acts as a specific substrate or inhibitor for studying the activity and kinetics of heparinases, sulfatases, and other glycosaminoglycan-degrading enzymes.
• Structure-Activity Relationship (SAR) Studies: Provides a defined molecular structure to investigate the specific sulfation patterns and sequences responsible for heparin's anticoagulant and other biological properties.
• Pharmaceutical Development: Employed in the research, development, and quality control of low molecular weight heparins (LMWHs) and other heparin-derived therapeutics.
• Biomarker Research: Utilized in the development of assays to detect and measure heparin disaccharides in biological samples as potential biomarkers.
• Glycobiology Tool: Serves as a critical reagent for probing carbohydrate-protein interactions and understanding the role of heparan sulfate proteoglycans in cell signaling and disease.

Basic Information

Product Name	Heparin Disaccharide I-A Sodium
CAS No.	136098-00-5
Molecular Formula	C14H21NO14S2 • xNa
Molecular Weight	Contact for details
Synonyms	δUA-GlcNS,6S Sodium Salt; 2-O-Sulfo-α-L-idopyranosyluronic acid-(1→4)-2-deoxy-6-O-sulfo-2-sulfamino-α-D-glucopyranose Sodium Salt; Heparin Disaccharide I-A (Sodium Salt); IdoA(2S)-GlcNS(6S); Unsaturated Heparin Disaccharide I-A Sodium; α-L-Idopyranosiduronic acid, 2-O-sulfo-, (1→4)-2-deoxy-2-sulfamino-6-O-sulfo-α-D-glucopyranose, sodium salt (1:?); Heparin-derived disaccharide standard I-A.
EINECS	Contact for details

Quality Control

Our Heparin Disaccharide I-A Sodium is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and analytical applications. A detailed Certificate of Analysis (COA) specifying purity, identity, and other critical parameters is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Specific Optical Rotation	Contact for details
NMR Profile	Conforms to structure

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.