Description

Palmitoyl Rhizoxin is a semi-synthetic derivative of the potent antitumor macrolide, rhizoxin. This compound is of significant interest in biochemical and pharmacological research due to its role as a stabilized, cell-permeable analog. It is primarily utilized by research institutions and pharmaceutical development laboratories investigating novel mechanisms of action for cancer therapeutics and studying tubulin polymerization dynamics.

Application

• Biochemical Research: Used as a critical tool compound for studying the inhibition of microtubule assembly and its effects on cellular division.
• Anticancer Agent Development: Serves as a reference standard and a lead compound in the discovery and optimization of new chemotherapeutic agents targeting tubulin.
• Mechanism of Action Studies: Employed in cell-based assays to elucidate the pathways of cytotoxicity and resistance mechanisms in various cancer cell lines.
• Pharmaceutical Intermediates: Acts as a key synthetic intermediate for the preparation of more complex derivatives with enhanced pharmacological profiles.
• Academic Research: Utilized in university and institutional labs for fundamental research in cell biology and chemical biology.

Basic Information

Product Name	Palmitoyl Rhizoxin
CAS No.	135819-69-1
Molecular Formula	C48H74O9
Molecular Weight	795.1 g/mol
Synonyms	Rhizoxin Palmitate; 16-O-Palmitoylrhizoxin; (3S,4aR,5S,6S,8E,12E,14aR,15R)-5-[(2S,3S,6S)-6-[(2E,4E)-5-[(1S)-1-Hydroxy-2-methylpentyl]-3-methylpenta-2,4-dien-2-yl]-3-methyl-5-oxooxan-2-yl]oxy-6,15-dimethyl-3-palmitoyloxy-1,2,3,4,4a,5,6,7,8,9,10,11,12,13,14,14a-hexadecahydrocyclopenta[a]cycloundecen-8-yl (2E,4E,6E,8E)-9-[(1S)-1-hydroxy-2-methylpentyl]-3,7-dimethyldeca-2,4,6,8-tetraenoate
EINECS	Contact for details

Quality Control

Our Palmitoyl Rhizoxin is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and high purity for research applications. Each lot is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your research integrity and documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation. Keep container dry and in a well-ventilated place.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content	≤ 1.0%
Residual Solvents	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.