Description

10,11-Methylenedioxycamptothecin is a semi-synthetic derivative of the potent topoisomerase I inhibitor, camptothecin. This compound is valued for its enhanced stability and potential therapeutic efficacy in oncology research. It is primarily utilized by pharmaceutical R&D departments and academic research institutions focused on developing novel anticancer agents and studying apoptosis mechanisms.

Application

• Pharmaceutical Research & Development: Serves as a key intermediate or active pharmaceutical ingredient (API) in the development of novel chemotherapeutic agents.
• Oncology Studies: Used in in vitro and in vivo studies to investigate its mechanism of action as a topoisomerase I inhibitor and its effects on various cancer cell lines.
• Biochemical Research: Employed in studies of DNA replication, transcription, and cell cycle arrest to understand the fundamental biology of cancer.
• Preclinical Development: A critical component in the preclinical evaluation pipeline for assessing the pharmacokinetics, pharmacodynamics, and toxicology of new camptothecin analogs.
• Reference Standard: Used as a high-purity analytical standard for quality control and method validation in pharmaceutical manufacturing.

Basic Information

Product Name	10,11-Methylenedioxycamptothecin
CAS No.	135415-73-5
Molecular Formula	C22H16N2O6
Molecular Weight	404.37 g/mol
Synonyms	10,11-Methylenedioxy-20(S)-camptothecin; MDC; 10,11-Methylenedioxycamptothecin; (S)-10,11-Methylenedioxycamptothecin; 20(S)-10,11-Methylenedioxycamptothecin; Camptothecin, 10,11-methylenedioxy-; 7-Ethyl-10,11-methylenedioxy-20-camptothecin
EINECS	Contact for details

Quality Control

Our 10,11-Methylenedioxycamptothecin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the stringent requirements for research and development use. Certificates of Analysis (COA) detailing all specifications and test results are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label or COA. Keep the container in a dry, well-ventilated place. For long-term storage, consider storing desiccated at -20°C.

Specification

Item	Specification
Appearance	Yellow to light yellow powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.