Description

Poststatin CAS NO 135219-43-1 is a specialized chemical compound belonging to the statin class, primarily recognized for its role as a potent and selective inhibitor of HMG-CoA reductase. This compound is of significant interest in pharmaceutical research and development for its potential in regulating cholesterol biosynthesis. It serves as a critical intermediate or active pharmaceutical ingredient (API) for researchers and manufacturers in the life sciences sector, particularly those focused on cardiovascular and metabolic disease therapeutics.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of advanced statin-based cholesterol-lowering drugs.
• Biochemical Research: Used as a reference standard or inhibitor in enzymatic studies targeting the mevalonate pathway and HMG-CoA reductase activity.
• API Development: Serves as an active pharmaceutical ingredient in the formulation of preclinical and clinical trial materials for hyperlipidemia treatment.
• Metabolic Pathway Analysis: A valuable tool for in vitro and in vivo studies investigating lipid metabolism and its regulation.
• High-Purity Reference Material: Supplied as a certified reference standard for quality control and analytical method development in pharmaceutical laboratories.

Basic Information

Product Name	Poststatin
CAS No.	135219-43-1
Molecular Formula	C25H38N2O5
Molecular Weight	446.59 g/mol
Synonyms	Poststatin; (3R,5R)-7-[(1S,2S,6S,8S,8aR)-8-[(2S)-2-Methylbutyryloxy]-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoic acid (2S)-2-Amino-3-methylbutylamide; HMG-CoA Reductase Inhibitor SRI-62320; SRI 62320; SRI62320
EINECS	Contact for details

Quality Control

Our Poststatin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identification by spectroscopic methods (IR, NMR), to ensure it meets stringent specifications for pharmaceutical research. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability, consistency, and compliance with your research or development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.