Description

L-Buthionine Sulfone is a key biochemical reagent and a stable sulfone derivative of the glutathione synthesis inhibitor, L-buthionine sulfoximine (BSO). Its primary value lies in its role as a critical research tool for studying cellular redox balance, glutathione metabolism, and oxidative stress pathways in both in vitro and in vivo models. This compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors, particularly for applications in cancer research, neurobiology, and toxicology studies.

Application

• Biochemical Research: A fundamental tool for depleting intracellular glutathione (GSH) levels to study oxidative stress, apoptosis, and the efficacy of chemotherapeutic agents.
• Pharmaceutical Development: Used in preclinical studies to investigate drug mechanisms that are dependent on or modulated by cellular glutathione concentrations.
• Cancer Research: Employed to sensitize cancer cells to radiation and chemotherapy by inhibiting glutathione synthesis, thereby compromising the cell's antioxidant defense system.
• Neuroscience Studies: Applied in models of neurodegenerative diseases to understand the role of oxidative damage and glutathione depletion in neuronal cell death.
• Toxicology & Cell Biology: Utilized to assess the impact of toxins and environmental stressors on cellular redox status and viability.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in analytical laboratories.

Basic Information

Product Name	L-Buthionine Sulfone
CAS No.	134859-31-7
Molecular Formula	C8H17NO4S
Molecular Weight	223.29 g/mol
Synonyms	L-Buthionine Sulfone; (2S)-2-Amino-4-(sulfobutyl)butanoic acid; Buthionine Sulfone; L-BSO Sulfone; NSC 326231; (S)-2-Amino-4-(3-hydroxy-3-oxopropylsulfonyl)butanoic acid; Glutathione synthesis inhibitor sulfone derivative
EINECS	Contact for details

Quality Control

Our L-Buthionine Sulfone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification by IR and NMR, purity assay by HPLC, and control of related substances and residual solvents, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with our stringent specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation	[α]20/D: Specific range provided on COA
Related Substances (HPLC)	Total impurities ≤2.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.