Description

5-(n-Ethyl-n-Isopropyl)Amiloridehydrochloride is a high-purity, specialized chemical derivative of the diuretic agent amiloride. This compound is of significant value in pharmaceutical research and development, particularly for studying epithelial sodium channel (ENaC) inhibition and related physiological pathways. It is primarily utilized by research scientists and development teams in the pharmaceutical, biotechnology, and life sciences sectors for preclinical studies and as a key intermediate in the synthesis of novel therapeutic agents.

Application

• Pharmaceutical Research: Serves as a critical reference standard and active pharmaceutical ingredient (API) intermediate in the development of novel diuretics and sodium channel blockers.
• Biochemical Studies: Used as a potent and selective inhibitor in in vitro and in vivo studies to investigate the function of epithelial sodium channels (ENaC).
• Metabolic Pathway Analysis: Employed in research focused on renal physiology, hypertension, and disorders of electrolyte and fluid balance.
• Chemical Synthesis: Acts as a key building block for the preparation of more complex amiloride analogs with tailored biological activity.
• Academic Research: Utilized in university and institutional labs for fundamental pharmacological and physiological research projects.

Basic Information

Product Name	5-(n-Ethyl-n-Isopropyl)Amiloridehydrochloride
CAS No.	134672-02-9
Molecular Formula	C11H19ClN6O • HCl
Molecular Weight	315.18 g/mol (Free base: 278.76 g/mol)
Synonyms	5-(N-Ethyl-N-isopropyl)amiloride hydrochloride; 5-(Ethyl(isopropyl)amino)-6-chloro-N-(diaminomethylidene)pyrazine-2-carboxamide hydrochloride; Amiloride 5-(N-Ethyl-N-isopropyl) analog hydrochloride; ENaC Inhibitor (5-(N-Ethyl-N-isopropyl)amiloride); 5-EIPA hydrochloride; 5-(N-Ethyl-N-isopropyl)amiloride HCl
EINECS	Contact for details

Quality Control

Our 5-(n-Ethyl-n-Isopropyl)Amiloridehydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR spectroscopy, and tests for residual solvents and heavy metals. A Certificate of Analysis (COA) detailing all specifications and results is provided with every shipment to ensure traceability and compliance with your research or development protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and performance.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.