Description

Pyridine-4-Sulfonyl Chloride is a versatile and highly reactive sulfonylating agent, essential for introducing the pyridine-4-sulfonyl moiety into target molecules. Its primary value lies in its role as a key synthetic intermediate for constructing complex chemical architectures, particularly in advanced pharmaceutical and agrochemical research. This compound is critically needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for applications such as medicinal chemistry, chemical biology, and material science.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the sulfonyl group imparts specific biological activity.
• Chemical Biology & Proteomics: Serves as a reactive handle for labeling, cross-linking, or modifying biomolecules like proteins and peptides in research applications.
• Material Science: Employed in the synthesis of functional polymers, liquid crystals, and advanced organic materials requiring sulfonamide linkages.
• Dye & Pigment Manufacturing: Acts as an intermediate in the synthesis of specialized dyes and pigments containing sulfonamide groups.
• Custom Synthesis & Contract Manufacturing: A key reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Item	Detail
Product Name	Pyridine-4-Sulfonyl Chloride
CAS No.	134479-04-2
Molecular Formula	C5H4ClNO2S
Molecular Weight	177.61 g/mol
Synonyms	4-Pyridinesulfonyl chloride; Isonicotinesulfonyl chloride; Pyridine-4-sulfonic acid chloride; 4-Pyridylsulfonyl chloride; p-Pyridinesulfonyl chloride; 4-Chlorosulfonylpyridine; Pyridine-4-sulfonylchloride
EINECS	Contact for details

Quality Control

Our Pyridine-4-Sulfonyl Chloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and development. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards, and specifications can be tailored to meet specific project requirements for advanced synthetic applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases, alcohols, and amines.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.