Description

Ca-074 is a potent, cell-permeable, and irreversible inhibitor of the cysteine protease calpain. This compound is a critical research tool for elucidating the role of calpain in various cellular processes, including signal transduction, apoptosis, and cytoskeletal remodeling. It is essential for researchers in the fields of neuroscience, cardiology, and cell biology who require high-purity biochemical reagents for mechanistic studies and target validation.

Application

• Biochemical Research: Used as a selective calpain inhibitor to study enzyme kinetics, substrate specificity, and the physiological roles of calpain isoforms in vitro and in cell-based assays.
• Neuroscience Studies: Investigates the involvement of calpain in neurodegenerative diseases, neuronal apoptosis, and synaptic plasticity, helping to identify potential therapeutic targets.
• Cardiovascular Research: Applied in models of ischemia-reperfusion injury and myocardial infarction to understand calpain-mediated proteolysis and cell death pathways.
• Cell Biology: Utilized to probe the function of calpain in cellular processes such as cell migration, proliferation, and cytoskeletal organization.
• Pharmaceutical Development: Serves as a reference compound and a lead structure in the discovery and development of novel calpain inhibitors for therapeutic applications.

Basic Information

Product Name	Ca-074
CAS No.	134448-10-5
Molecular Formula	C₂₀H₃₇N₃O₇S
Molecular Weight	463.59 g/mol
Synonyms	N-(L-3-trans-Propylcarbamoyloxirane-2-carbonyl)-L-isoleucyl-L-proline; Calpain Inhibitor III; (2S)-1-[(2S)-2-[[(2S,3S)-3-[[(2S)-1-Oxo-3-phenylpropan-2-yl]carbamoyl]oxiran-2-yl]formamido]-4-methylpentanoyl]pyrrolidine-2-carboxylic acid; L-3-carboxy-trans-2,3-epoxypropionyl-leucylagmatine; Z-LLY-CHN2; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our Ca-074 is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity suitable for advanced research applications. Each lot is characterized by multiple analytical techniques, including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your research integrity and documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.