Description

Diiodo-Philanthotoxin-343-Lysine CAS NO 134419-07-1 is a chemically modified analog of philanthotoxin, a potent non-competitive antagonist of ionotropic glutamate receptors, specifically engineered for enhanced research utility. This compound is of significant value in neuroscience and pharmacology for studying the structure and function of glutamate-gated ion channels, such as AMPA and NMDA receptors. It is primarily utilized by research institutions, pharmaceutical R&D departments, and biotechnology companies engaged in neurobiological research, drug discovery for neurological disorders, and the development of novel insecticidal agents.

Application

• Neuroscience Research: A critical tool for probing the biophysical properties and modulation of ionotropic glutamate receptors (iGluRs) in synaptic transmission studies.
• Pharmacological Profiling: Used in high-throughput screening and lead optimization programs targeting neurological conditions like epilepsy, stroke, and neurodegenerative diseases.
• Insecticide Mode-of-Action Studies: Serves as a reference compound for investigating the neurotoxic effects on insect nicotinic acetylcholine receptors, aiding in the development of new agrochemicals.
• Biochemical Assay Development: Employed as a standard or inhibitor in receptor binding assays and functional electrophysiology experiments.
• Academic Research: Fundamental research in universities and institutes focusing on channel physiology, neuropharmacology, and toxicology.
• Chemical Biology: Acts as a molecular probe for labeling or cross-linking studies due to its modified lysine moiety and iodine atoms.

Basic Information

Item	Detail
Product Name	Diiodo-Philanthotoxin-343-Lysine
CAS No.	134419-07-1
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Diiodo-PhTX-343-Lys; Philanthotoxin-343 Diiodo Lysine derivative; PhTX-343 analog; Glutamate receptor antagonist analog; Non-competitive AMPA receptor blocker; Ion channel research compound; Neuropharmacology research chemical
EINECS	Contact for details

Quality Control

Our Diiodo-Philanthotoxin-343-Lysine is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and reliability for sensitive research applications. Each lot undergoes comprehensive analytical characterization, including purity verification by HPLC and structural confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting key specifications to support your research integrity and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	Contact for details
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.