Description

n-(Deoxyguanosin-8-Yl)-2-Aminopyrene is a structurally defined, high-purity biochemical standard crucial for advanced research and analytical applications. This compound serves as a critical reference material for studying DNA adduct formation and mutagenesis, providing researchers with a reliable benchmark for accuracy and reproducibility. It is primarily utilized by analytical laboratories, academic research institutions, and pharmaceutical R&D departments focused on genetic toxicology, biomarker discovery, and carcinogenesis studies.

Application

• DNA Adduct Research: Used as a certified reference standard for the identification and quantification of specific polycyclic aromatic hydrocarbon (PAH)-DNA adducts.
• Biomarker Analysis: Essential in developing and validating sensitive analytical methods (e.g., LC-MS/MS, 32P-postlabeling) for detecting exposure biomarkers in biological samples.
• Genetic Toxicology Studies: Employed in *in vitro* and *in vivo* studies to understand the mutagenic potential and repair mechanisms of specific DNA lesions.
• Method Development & Validation: Serves as a primary standard for calibrating instruments and ensuring the accuracy of assays in environmental and biological monitoring.
• Pharmaceutical Safety Assessment: Utilized in the preclinical safety evaluation of new chemical entities to assess genotoxic risk.
• Forensic and Environmental Analysis: Aids in the forensic investigation of exposure sources and environmental health risk assessments related to PAH contamination.

Basic Information

Product Name	n-(Deoxyguanosin-8-Yl)-2-Aminopyrene
CAS No.	134249-04-0
Molecular Formula	C26H24N6O4
Molecular Weight	484.51 g/mol
Synonyms	N-(Deoxyguanosin-8-yl)-2-AP; 2-Aminopyrene-deoxyguanosine adduct; 8-(2-Aminopyren-1-yl)-2'-deoxyguanosine; dG-AP; N-(2'-Deoxyguanosin-8-yl)-2-aminopyrene; PAH-DNA Adduct Standard; 2-AP-dG; DNA-2-Aminopyrene Adduct
EINECS	Contact for details

Quality Control

Our n-(Deoxyguanosin-8-Yl)-2-Aminopyrene is manufactured under strict quality protocols to ensure batch-to-batch consistency and high purity, meeting the exacting requirements of research and analytical applications. Each lot is thoroughly characterized using advanced spectroscopic and chromatographic techniques. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and stability is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a desiccated environment. This compound is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, keep under inert atmosphere. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum consistent with structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 3.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.