Description

Kifunensine Diacetonide CAS NO 134234-43-8 is a protected derivative of the potent α-mannosidase I inhibitor, kifunensine, designed for enhanced stability and handling in advanced research and synthesis. This high-purity chemical intermediate is critical for researchers developing novel glycosylation inhibitors and exploring N-linked oligosaccharide processing in glycobiology. It is primarily utilized by pharmaceutical R&D teams, biotechnology firms, and academic laboratories focused on metabolic disease research, antiviral drug discovery, and the production of homogeneous glycoproteins.

Application

• Glycobiology Research: A key tool for studying the role of α-mannosidase I in N-linked glycan processing and endoplasmic reticulum-associated degradation (ERAD).
• Pharmaceutical Intermediate: Serves as a protected synthetic precursor in the development of novel glycosidase inhibitors for therapeutic applications.
• Biologics Development: Used to produce homogeneous glycoprotein structures by inhibiting specific glycosylation pathways, aiding in structure-activity relationship studies.
• Antiviral & Anticancer Agent Research: Investigated for its potential to disrupt viral envelope glycoprotein maturation and tumor cell surface glycosylation.
• Enzyme Mechanism Studies: Employed as a specific inhibitor to elucidate the catalytic mechanism and biological function of Class I mannosidases.
• Standards & Reference Material: Provides a stable, high-purity standard for analytical method development and quality control in related biochemical assays.

Basic Information

Product Name	Kifunensine Diacetonide
CAS No.	134234-43-8
Molecular Formula	C₁₇H₂₈N₂O₇
Molecular Weight	372.42 g/mol
Synonyms	(2R,3R,4R,5S)-2,3:4,5-Bis-O-(1-methylethylidene)-1,2,3,4,5-pentanepentol 1-(L-3a,8a-cis-1,2,3,5,8,8a-hexahydro-3a,8a-dihydroxyindolizino[1,2-a]pyrazin-7-yl)-; Kifunensine Bisacetonide; Kifunensine Diacetonide; Kifunensine Di-O-isopropylidene Derivative; Protected Kifunensine
EINECS	Contact for details

Quality Control

Our Kifunensine Diacetonide is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing results from HPLC, NMR, and mass spectrometry. We adhere to stringent quality management protocols suitable for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.