Description

3,4-Difluoro-5-(Trifluoromethyl)Benzaldehyde is a high-value, multi-fluorinated aromatic aldehyde building block. This compound matters for its unique trifluoromethyl and difluoro substitution pattern, which imparts desirable properties like enhanced lipophilicity, metabolic stability, and electronic effects into target molecules. It is primarily needed by pharmaceutical and agrochemical R&D teams for the synthesis of novel active ingredients, particularly in the development of small molecule drugs and advanced crop protection agents.

Application

• Pharmaceutical Intermediate: A key synthon for constructing bioactive molecules, especially kinase inhibitors, anti-inflammatory agents, and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where the fluorine atoms improve efficacy and environmental profile.
• Liquid Crystal Materials: Serves as a precursor for fluorine-containing liquid crystal compounds used in display technologies.
• Organic Electronic Materials: Employed in the development of organic semiconductors and charge-transport materials for OLEDs and photovoltaics.
• Advanced Polymer Modification: Acts as a monomer or cross-linking agent to introduce fluorine groups into specialty polymers, enhancing chemical and thermal resistance.
• Complex Ligand Synthesis: Utilized in organometallic chemistry and catalysis to create novel fluorinated ligands for transition metal complexes.

Basic Information

Product Name	3,4-Difluoro-5-(Trifluoromethyl)Benzaldehyde
CAS No.	134099-28-8
Molecular Formula	C8H3F5O
Molecular Weight	210.10 g/mol
Synonyms	5-(Trifluoromethyl)-3,4-difluorobenzaldehyde; 3,4-Difluoro-5-(trifluoromethyl)benzaldehyde; 3,4-Difluoro-α,α,α-trifluorotoluic aldehyde; Benzaldehyde, 3,4-difluoro-5-(trifluoromethyl)-; 3,4-Difluoro-5-trifluoromethylbenzaldehyde
EINECS	Contact for details

Quality Control

Our 3,4-Difluoro-5-(Trifluoromethyl)Benzaldehyde is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our production adheres to cGMP standards where applicable, ensuring reliable consistency and traceability for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Recommended storage temperature is 2-8°C for long-term stability. The container should be kept tightly sealed in a dry environment to minimize exposure to moisture. Keep away from strong oxidizing agents and bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.