Description

Tyrphostin B7 is a potent and selective inhibitor of protein tyrosine kinases, specifically targeting the epidermal growth factor receptor (EGFR) signaling pathway. This compound is a critical research tool for studying cellular signal transduction mechanisms related to cell proliferation, differentiation, and oncogenesis. It is primarily utilized by researchers and developers in the pharmaceutical and biotechnology sectors for drug discovery and biochemical research.

Application

• Biochemical Research: Used as a selective EGFR tyrosine kinase inhibitor to study signal transduction pathways in cell cultures.
• Oncology Research: Investigated for its potential anti-proliferative effects on various cancer cell lines, aiding in the understanding of tumor biology.
• Drug Discovery & Development: Serves as a reference standard and a lead compound in the development of novel targeted cancer therapeutics.
• Cellular Mechanism Studies: Employed to elucidate the role of EGFR in processes like cell growth, migration, and apoptosis.
• Academic Research: A key reagent in university and institutional labs for fundamental studies in molecular biology and pharmacology.

Basic Information

Product Name	Tyrphostin B7
CAS No.	134036-53-6
Molecular Formula	C16H12N2O3
Molecular Weight	280.28 g/mol
Synonyms	AG 555; Tyrphostin AG 555; RG 50810; 2-[(3-Bromophenyl)amino]-3-cyano-5-ethyl-7,8-dihydro-4H-pyrano[4,3-d]pyrimidin-4-one; 3-Cyano-5-ethyl-2-[(3-bromophenyl)amino]-7,8-dihydro-4H-pyrano[4,3-d]pyrimidin-4-one; B7 (Tyrphostin); EGFR Tyrosine Kinase Inhibitor AG555
EINECS	Contact for details

Quality Control

Our Tyrphostin B7 is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each batch is accompanied by comprehensive analytical documentation, including HPLC chromatograms and NMR data. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	Off-white to yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.