Description

2’-Epi Docetaxel is a key pharmaceutical intermediate and a stereoisomer of the potent anticancer drug Docetaxel. This compound is of significant interest for research and development in advanced oncology therapeutics, particularly in structure-activity relationship (SAR) studies and the synthesis of novel taxane derivatives. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and manufacturers of active pharmaceutical ingredients (APIs) focused on anticancer agents.

Application

• Pharmaceutical Intermediate: Critical starting material or intermediate in the synthesis of Docetaxel and related taxane-based anticancer drugs.
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies to understand the impact of stereochemistry on biological activity and toxicity.
• Reference Standard: Serves as a high-purity analytical standard for quality control and impurity profiling in Docetaxel API manufacturing.
• Process Chemistry: Employed in the development and optimization of synthetic pathways for complex taxane molecules.
• Academic Research: Utilized in university and institutional labs for biochemical and pharmacological studies targeting microtubule stabilization.

Basic Information

Product Name	2’-Epi Docetaxel
CAS No.	133577-33-0
Molecular Formula	C43H53NO14
Molecular Weight	807.89 g/mol
Synonyms	(2R,3S)-N-Carboxy-3-phenylisoserine, N-tert-butyl ester, 13-ester with 5β,20-epoxy-1,2α,4,7β,10β,13α-hexahydroxytax-11-en-9-one 4-acetate 2-benzoate; 2'-epi-Docetaxel; 2'-Epimer of Docetaxel; Docetaxel Impurity F (EP); Docetaxel Related Compound F (USP); Taxotere Impurity F
EINECS	Contact for details

Quality Control

Our 2’-Epi Docetaxel is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via IR and NMR, to ensure it meets the stringent requirements for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided and can be tailored to meet specific pharmacopeial standards (e.g., USP, EP) upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.