Description

R-Erythro-Taxotere is a specific stereoisomer of the potent anticancer agent Docetaxel, identified by CAS NO 133577-32-9. This compound is of critical importance in pharmaceutical research and development, particularly for investigating structure-activity relationships and the stereospecific biological effects of taxane derivatives. It is primarily needed by research institutions, pharmaceutical companies, and contract research organizations (CROs) engaged in oncology drug discovery, process chemistry, and the development of novel chemotherapeutic agents.

Application

• Pharmaceutical Reference Standard: Serves as a critical analytical standard for quality control and method development in the production of taxane-based APIs.
• Oncology Research: Used in preclinical studies to investigate the efficacy, metabolism, and toxicity profile of specific Docetaxel stereoisomers.
• Process Chemistry & Impurity Profiling: Essential for identifying and quantifying isomeric impurities during the synthesis and purification of Docetaxel.
• Metabolite Studies: Employed in ADME (Absorption, Distribution, Metabolism, and Excretion) research to understand the metabolic pathways of taxane drugs.
• Formulation Development: Aids in the development of novel drug delivery systems, such as nanoparticles or liposomes, for targeted cancer therapy.
• Academic Research: Used in university and institutional labs for fundamental studies in medicinal chemistry and chemical biology.

Basic Information

Product Name	R-Erythro-Taxotere
CAS No.	133577-32-9
Molecular Formula	C43H53NO14
Molecular Weight	807.88 g/mol
Synonyms	(2R,3S)-N-Carboxy-3-phenylisoserine, N-tert-butyl ester, 13-ester with 5β,20-epoxy-1,2α,4,7β,10β,13α-hexahydroxytax-11-en-9-one 4-acetate 2-benzoate; R-Erythro-Docetaxel; Docetaxel Impurity F (Erythro isomer); (αR,βS)-N-(tert-Butoxycarbonyl)-β-phenylisoserine Docetaxel Ester; 1,7β,10β-Triacetoxy-13α-{[(2R,3S)-3-{[(tert-butoxy)carbonyl]amino}-2-hydroxy-3-phenylpropanoyl]oxy}-5β,20-epoxy-9-oxotax-11-en-2α-yl benzoate
EINECS	Contact for details

Quality Control

Our R-Erythro-Taxotere is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the exacting standards required for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatographic data are provided to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.