Description

Tyrphostin Ag 528 is a potent and selective inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase. This compound is a valuable research-grade biochemical tool for studying signal transduction pathways, cellular proliferation, and apoptosis. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies focused on oncology and cell biology.

Application

• Biochemical Research: Used as a selective EGFR tyrosine kinase inhibitor to elucidate signaling mechanisms in cell culture studies.
• Oncology Research: Investigated for its effects on cancer cell growth, proliferation, and programmed cell death (apoptosis).
• Signal Transduction Studies: A key tool for probing the role of EGFR in various cellular pathways and disease models.
• Drug Discovery & Development: Serves as a reference compound or lead molecule in the development of novel targeted cancer therapeutics.
• Academic & Pharmaceutical R&D: Essential for basic research and pre-clinical studies in molecular biology and pharmacology departments.

Basic Information

Product Name	Tyrphostin Ag 528
CAS No.	133550-49-9
Molecular Formula	C16H12N2O3
Molecular Weight	280.28 g/mol
Synonyms	AG 528; Tyrphostin AG 528; AG-528; 4-Hydroxy-3,5-dimethoxybenzylidene malononitrile; 2-[(3,5-Dimethoxy-4-hydroxyphenyl)methylene]malononitrile; EGFR Tyrosine Kinase Inhibitor AG 528; RG 50810; RG-50810
EINECS	Contact for details

Quality Control

Our Tyrphostin Ag 528 is produced under strict quality management systems to ensure batch-to-batch consistency and reliability for research applications. Each lot undergoes comprehensive analytical testing, including identity confirmation, purity assessment, and impurity profiling. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment to guarantee compliance with your research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing at -20°C under an inert atmosphere.

Specification

Item	Specification
Appearance	Yellow to brown powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.5%
Solubility	Soluble in DMSO, DMF; sparingly soluble in ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.