Description

Tyrphostin Ag 835 is a potent and selective inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase. This compound is a critical research tool for studying signal transduction pathways involved in cell proliferation, differentiation, and oncogenesis. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies focused on cancer research and drug discovery.

Application

• Biochemical Research: A key reagent for investigating EGFR-mediated signaling cascades and their role in cellular processes.
• Cancer Research: Used in in vitro and in vivo studies to elucidate the mechanisms of tumor growth and to evaluate potential therapeutic targets.
• Drug Discovery & Development: Serves as a reference standard and a pharmacological tool in high-throughput screening and lead optimization for novel oncology therapeutics.
• Cellular Pathway Analysis: Employed to dissect the specific contributions of EGFR tyrosine kinase activity in complex biological systems and disease models.

Basic Information

Product Name	Tyrphostin Ag 835
CAS No.	133550-37-5
Molecular Formula	C₁₇H₁₄N₂O₃
Molecular Weight	294.31 g/mol
Synonyms	AG 835; Tyrphostin AG 835; 4-[(3-Bromophenyl)amino]-6,7-dimethoxyquinazoline; NSC 693871; EGFR Tyrosine Kinase Inhibitor AG835; 6,7-Dimethoxy-4-[(3-bromophenyl)amino]quinazoline
EINECS	Contact for details

Quality Control

Our Tyrphostin Ag 835 is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research applications. A detailed Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C for long-term stability. The compound is light-sensitive and should be handled under appropriate conditions to maintain its integrity.

Specification

Item	Specification
Appearance	Off-white to light yellow powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.