Description

Tyrphostin B48 is a potent and selective inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase, a key target in cellular signaling pathways. This compound is a critical research tool for investigating the role of EGFR in cell proliferation, differentiation, and oncogenesis. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in cancer research, signal transduction studies, and the development of targeted therapeutics.

Application

• Biochemical Research: A key reagent for studying EGFR-mediated signal transduction pathways and their role in cellular processes.
• Oncology Research: Used in in vitro and in vivo studies to investigate the mechanisms of tumor growth and to evaluate potential anti-cancer strategies.
• Drug Discovery & Development: Serves as a reference compound and a pharmacological tool for screening and validating new EGFR-targeting drug candidates.
• Cell Biology Studies: Employed to modulate EGFR activity to understand its function in cell cycle regulation, apoptosis, and differentiation.
• Academic & Institutional Research: A standard compound for graduate and post-graduate level research in molecular biology and pharmacology.

Basic Information

Product Name	Tyrphostin B48
CAS No.	133550-35-3
Molecular Formula	C17H14N2O3
Molecular Weight	294.31 g/mol
Synonyms	AG 555; Tyrphostin AG 555; (E)-2-Cyano-3-(3,4-dihydroxyphenyl)-N-(phenylmethyl)-2-propenamide; RG 13022; EGFR Tyrosine Kinase Inhibitor AG555; α-Cyano-3,4-dihydroxy-N-benzylcinnamamide
EINECS	Contact for details

Quality Control

Our Tyrphostin B48 is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and reliability for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and other critical parameters. We adhere to high-purity standards suitable for pharmaceutical and biochemical research, ensuring the integrity of your experimental data.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider keeping the product at 2-8°C. Handle and store in accordance with good laboratory practices.

Specification

Item	Specification
Appearance	Off-white to yellow crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.