Description

Tyrphostin B46 is a potent and selective chemical inhibitor primarily used in biochemical and pharmacological research. This compound is valued for its ability to modulate specific cellular signaling pathways, making it a critical tool for investigating disease mechanisms and potential therapeutic targets. It is essential for researchers and development teams in the pharmaceutical, biotechnology, and academic sectors focused on kinase-related studies and drug discovery programs.

Application

• Biochemical Research: A key reagent for studying protein tyrosine kinase inhibition and related signal transduction cascades in vitro.
• Pharmacological Studies: Used to investigate the role of specific kinases in cellular models of inflammation, cancer, and metabolic disorders.
• Drug Discovery & Development: Serves as a reference standard and a lead compound scaffold in the design and screening of novel therapeutic agents.
• Academic Research: Employed in university and institutional labs for fundamental research into cell biology and molecular mechanisms.
• Diagnostic Development: Potential use in developing assays and kits for kinase activity measurement and target validation.

Basic Information

Product Name	Tyrphostin B46
CAS No.	133550-34-2
Molecular Formula	C16H12N2O3
Molecular Weight	280.28 g/mol
Synonyms	AG 490; Tyrphostin AG 490; NSC 693823; (E)-2-Cyano-3-(3,4-dihydroxyphenyl)-N-(phenylmethyl)-2-propenamide; α-Cyano-(3,4-dihydroxy)-N-benzylcinnamamide; Benzyl 2-cyano-3-(3,4-dihydroxyphenyl)acrylate; JANEX-1
EINECS	Contact for details

Quality Control

Our Tyrphostin B46 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for research applications. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and consistent performance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	Yellow to brown powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.