Description

Tyrphostin B44 CAS NO 133550-32-0 is a potent and selective inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase, belonging to the tyrphostin class of compounds. This specificity makes it a critical research tool for studying signal transduction pathways involved in cell proliferation, differentiation, and oncogenesis. It is primarily utilized by researchers and developers in the pharmaceutical, biotechnology, and life sciences sectors for biochemical and pharmacological studies.

Application

• Biochemical Research: Used as a selective EGFR tyrosine kinase inhibitor to study receptor-mediated signaling cascades and their role in cellular processes.
• Oncology Research: Investigated for its potential to inhibit the growth of EGFR-dependent tumor cell lines in preclinical studies.
• Signal Transduction Studies: A key reagent for elucidating the mechanisms of growth factor action and downstream effector pathways.
• Drug Discovery & Development: Serves as a reference compound or lead structure in the design and screening of novel targeted cancer therapeutics.
• Academic Research: Employed in university and institutional labs for fundamental research in cell biology and molecular pharmacology.

Basic Information

Product Name	Tyrphostin B44
CAS No.	133550-32-0
Molecular Formula	C16H12N2O3
Molecular Weight	280.28 g/mol
Synonyms	AG 555; Tyrphostin AG 555; (E)-2-Cyano-3-(3,4-dihydroxyphenyl)-N-(phenylmethyl)-2-propenamide; RG 50810; B44; EGFR Tyrosine Kinase Inhibitor B44; ZD-1611
EINECS	Contact for details

Quality Control

Our Tyrphostin B44 is produced under strict quality management protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for research-grade chemicals, ensuring reliable and reproducible performance in your experiments.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, well-ventilated area. Keep the container sealed to protect this light-sensitive compound from degradation.

Specification

Item	Specification
Appearance	Yellow to brown powder
Identification (HPLC/IR)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Solubility	Soluble in DMSO, DMF; sparingly soluble in ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.