Description

Tyrphostin Ag 538 is a potent and selective small-molecule inhibitor of the insulin-like growth factor 1 receptor (IGF-1R) tyrosine kinase. This compound is a critical research tool for investigating signal transduction pathways involved in cell growth, proliferation, and survival, particularly in oncology and metabolic disease research. It is essential for pharmaceutical R&D, academic biochemistry laboratories, and biotechnology companies focused on targeted cancer therapy development.

Application

• Biochemical Research: Used as a selective inhibitor to study IGF-1R signaling cascades and their role in cellular processes.
• Oncology Research: Investigated for its potential to inhibit the growth and survival of cancer cell lines that are dependent on IGF-1R pathways.
• Drug Discovery & Development: Serves as a lead compound or pharmacological tool in high-throughput screening and target validation for new therapeutic agents.
• Signal Transduction Studies: Employed to dissect the specific roles of IGF-1R in complex cellular signaling networks, often in comparison with other receptor tyrosine kinases.
• Metabolic Disease Research: Utilized in studies exploring the connection between IGF-1R signaling, insulin resistance, and related metabolic disorders.

Basic Information

Product Name	Tyrphostin Ag 538
CAS No.	133550-18-2
Molecular Formula	C16H12N2O3
Molecular Weight	280.28 g/mol
Synonyms	AG 538; Tyrphostin AG 538; (E)-2-Cyano-3-(3,4-dihydroxyphenyl)-N-(phenylmethyl)-2-propenamide; AG-538; NSC 654705; IGF-1R Inhibitor AG538; IGF1R Inhibitor AG-538; Benzyl (2E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enoate
EINECS	Contact for details

Quality Control

Our Tyrphostin Ag 538 is produced and handled under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity verification and spectroscopic methods for structural confirmation, to ensure consistency and reliability for research applications. A detailed Certificate of Analysis (COA) is provided with every shipment to guarantee traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing at -20°C under an inert atmosphere.

Specification

Item	Specification
Appearance	Yellow to brown powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.