Description

γ-Secretase Inhibitor CAS NO 133407-83-7 is a potent, cell-permeable small molecule inhibitor of the γ-secretase enzyme complex. This compound is a critical research tool for modulating the Notch signaling pathway and amyloid precursor protein (APP) processing, with significant implications for understanding fundamental cellular mechanisms. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on oncology, neurodegenerative diseases, and developmental biology.

Application

• Notch Signaling Pathway Research: Fundamental tool for studying cell differentiation, proliferation, and apoptosis in cancer and developmental biology.
• Alzheimer's Disease Research: Investigates the role of γ-secretase in the production of amyloid-beta peptides, a key pathological hallmark.
• Oncology Drug Discovery: Used in target validation and preclinical studies for cancers where Notch signaling is dysregulated (e.g., T-cell acute lymphoblastic leukemia, breast cancer).
• Cell Biology & Biochemistry: Employed in in vitro and cellular assays to dissect the function of the γ-secretase complex and its substrates.
• High-Throughput Screening (HTS): Serves as a reference compound or positive control in screening campaigns for novel γ-secretase modulators or inhibitors.
• Mechanistic Studies: Helps elucidate the processing of other γ-secretase substrates beyond APP and Notch, such as CD44, E-cadherin, and N-cadherin.

Basic Information

Product Name	γ-Secretase Inhibitor
CAS No.	133407-83-7
Molecular Formula	C₂₃H₃₂N₄O₄S
Molecular Weight	460.59 g/mol
Synonyms	N-[N-(3,5-Difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester; DAPT; GS Inhibitor IX; LY-374973; (S)-tert-Butyl 2-((S)-2-(2-(3,5-difluorophenyl)acetamido)propanamido)-2-phenylacetate; γ-Secretase Inhibitor DAPT; Notch Inhibitor DAPT
EINECS	Contact for details

Quality Control

Our γ-Secretase Inhibitor is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (NMR, MS), to ensure high batch-to-batch consistency and reliability for sensitive research applications. A comprehensive Certificate of Analysis (COA) detailing purity, potency, and analytical results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, moisture-free environment. The product is hygroscopic (moisture-sensitive) and should be allowed to equilibrate to room temperature in a desiccator before opening to prevent condensation. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%
Solubility	Soluble in DMSO, DMF; sparingly soluble in ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.