Description

Mg-132 is a potent and selective proteasome inhibitor widely used in biochemical and pharmaceutical research. This compound is crucial for studying cellular processes like protein degradation, apoptosis, and inflammation pathways. It is an essential tool for researchers in pharmaceutical development, oncology research, and neurobiology, providing a reliable means to investigate disease mechanisms and potential therapeutic targets.

Application

• Biochemical Research: A key reagent for studying the ubiquitin-proteasome system (UPS) and its role in cellular regulation.
• Pharmaceutical Development: Used in target validation and as a lead compound for developing novel anti-cancer and anti-inflammatory agents.
• Oncology Studies: Employed to induce apoptosis in cancer cell lines and to investigate tumor growth and metastasis mechanisms.
• Neurodegenerative Disease Research: Applied in models of Alzheimer's and Parkinson's disease to study protein aggregation and neuronal cell death.
• Inflammation and Immunology: Used to modulate NF-κB signaling pathways and study immune cell function.
• Academic Research: A standard tool in university and institutional labs for fundamental research in cell biology and molecular pharmacology.

Basic Information

Product Name	Mg-132
CAS No.	133407-82-6
Molecular Formula	C₂₂H₃₃N₃O₅
Molecular Weight	419.52 g/mol
Synonyms	Z-Leu-Leu-Leu-al; Carbobenzoxy-Leu-Leu-Leucinal; Cbz-LLL-al; MG-132; Z-LLL-CHO; N-[(phenylmethoxy)carbonyl]-L-leucyl-N-[(1S)-1-[[(2S)-1-[[(2S)-1-oxo-3-phenyl-2-propanyl]amino]-4-methyl-1-oxopentyl]amino]-4-methyl-1-oxopentyl]-L-leucinamide; Proteasome Inhibitor MG-132
EINECS	Contact for details

Quality Control

Our Mg-132 is produced under strict quality management systems to ensure batch-to-batch consistency and reliability for critical research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity verification and identity confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Solubility	Soluble in DMSO, DMF; Slightly soluble in ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.