Description

N(Alpha)-Tosyl-Glycyl-3-Amidinophenylalanine is a specialized synthetic peptide derivative featuring a tosyl-protected N-terminus and a key amidinophenylalanine residue. This compound is primarily valued as a high-purity biochemical building block and a critical intermediate in pharmaceutical research and development. It is essential for researchers and manufacturers in the fields of protease inhibitor design, medicinal chemistry, and the synthesis of novel therapeutic peptides.

Application

• Protease Inhibitor Research: Serves as a key scaffold or intermediate in the development of selective serine protease inhibitors.
• Pharmaceutical Intermediates: Used in the synthesis of active pharmaceutical ingredients (APIs) targeting coagulation and inflammatory pathways.
• Biochemical Tool Compound: Employed in enzymatic studies and assay development to investigate protease activity and mechanism.
• Medicinal Chemistry & Drug Discovery: Acts as a building block for constructing peptide mimetics and optimizing drug candidate pharmacokinetics.
• Academic & Contract Research: Utilized in university and CRO laboratories for fundamental research in biochemistry and peptide science.

Basic Information

Product Name	N(Alpha)-Tosyl-Glycyl-3-Amidinophenylalanine
CAS No.	133397-82-7
Molecular Formula	C19H22N4O5S
Molecular Weight	418.47 g/mol
Synonyms	Glycyl-3-amidinophenylalanine N-α-tosylate; N-α-Tosyl-Gly-3-amidinophenylalanine; Tos-Gly-3-Amf-OH; 3-Amidinophenylalanyl-glycine N-tosyl derivative; BOC-Gly-3-Amf-OH (related precursor); (S)-2-((2-((4-Methylphenyl)sulfonamido)acetamido)-3-(3-carbamimidoylphenyl)propanoic acid
EINECS	Contact for details

Quality Control

Our N(Alpha)-Tosyl-Glycyl-3-Amidinophenylalanine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the exacting standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Assay (HPLC)	≥ 95.0%
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.