Description

N(Alpha)-Tosylglycyl-3-Amidinophenylalanine Methyl Ester is a specialized synthetic peptide derivative featuring a tosyl-protected glycine residue and an amidinophenylalanine methyl ester moiety. This compound is of significant value as a key intermediate or building block in advanced pharmaceutical research and development. It is primarily utilized by researchers and manufacturers in the life sciences sector for applications such as protease inhibitor design, medicinal chemistry, and the synthesis of novel bioactive molecules.

Application

• Protease Inhibitor Research: Serves as a crucial intermediate in the design and synthesis of potent serine protease inhibitors, particularly targeting enzymes like trypsin and thrombin.
• Medicinal Chemistry & Drug Discovery: Used as a sophisticated building block for constructing peptide mimetics and novel pharmacophores in lead optimization programs.
• Biochemical Tool Development: Employed in the development of activity-based probes and diagnostic agents for studying protease activity and function in biological systems.
• Pharmaceutical Intermediate: Acts as a key synthetic precursor in the multi-step production of candidate drug compounds for cardiovascular and inflammatory diseases.

Basic Information

Product Name	N(Alpha)-Tosylglycyl-3-Amidinophenylalanine Methyl Ester
CAS No.	133397-81-6
Molecular Formula	C21H26N4O5S
Molecular Weight	446.52 g/mol
Synonyms	N-α-Tosylglycyl-3-amidinophenylalanine methyl ester; Glycine, N-[(4-methylphenyl)sulfonyl]-, 3-(aminoiminomethyl)-L-phenylalanine methyl ester; Tos-Gly-3-Amf-OMe; N-Tosyl-Gly-3-amidino-Phe-OMe; 3-Amidino-L-phenylalanine, N-tosylglycyl-, methyl ester; Methyl N-tosylglycyl-3-amidino-L-phenylalaninate
EINECS	Contact for details

Quality Control

Our production of N(Alpha)-Tosylglycyl-3-Amidinophenylalanine Methyl Ester adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity, essential for research reproducibility. Each lot undergoes comprehensive analytical characterization, including HPLC for purity, NMR and MS for structural confirmation, and chiral analysis. Certificates of Analysis (COA) detailing all specifications are provided to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider desiccation or an inert atmosphere to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.