Description

Dideaza-Philanthotoxin-12 CAS NO 133358-74-4 is a synthetic analog of philanthotoxin, a potent neuroactive compound originally derived from wasp venom. This derivative is specifically engineered for research into ionotropic glutamate receptors, particularly AMPA and kainate subtypes, serving as a valuable non-competitive antagonist. It is a critical tool for neuroscientists and pharmacologists in academic, pharmaceutical, and biotechnology sectors investigating synaptic transmission, neurological disorders, and the development of novel neuroprotective agents.

Application

• Neuroscience Research: Fundamental studies on the function and modulation of ionotropic glutamate receptors (AMPA/kainate) in the central nervous system.
• Pharmacological Profiling: Used as a reference standard and probe compound for screening and characterizing new neuroactive substances in drug discovery pipelines.
• Mechanistic Studies: Investigation of channel block mechanisms and structure-activity relationships (SAR) of polyamine-based neurotoxins.
• Neuroprotection Research: Exploring potential pathways for mitigating excitotoxicity associated with stroke, traumatic brain injury, and neurodegenerative diseases.
• Biochemical Assay Development: A key component in developing and validating high-throughput screening assays for receptor antagonists.
• Academic & Institutional Research: Essential for university and government labs conducting cutting-edge research in neurobiology and cellular signaling.

Basic Information

Product Name	Dideaza-Philanthotoxin-12
CAS No.	133358-74-4
Molecular Formula	C19H33N5O4
Molecular Weight	395.50 g/mol
Synonyms	Dideaza-PhTX-12; Dideaza-PhTX12; 1,5,9,13-Tetraazatridecane-2,6,10,14-tetrone, 13-[(4-aminobutyl)amino]-4,8,12-triaza-15-phenyl-; Philanthotoxin-12 Dideaza Analog; PhTX-12 Dideaza Derivative; AMPA Receptor Antagonist (Dideaza); Non-competitive Glutamate Receptor Blocker
EINECS	Contact for details

Quality Control

Every batch of Dideaza-Philanthotoxin-12 is produced and analyzed under strict quality management protocols to ensure the highest standards of purity and consistency for research applications. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This compound is hygroscopic (moisture-sensitive); ensure the container is sealed under inert atmosphere or with desiccant to maintain stability. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.