Description

Lactacystin is a highly potent and selective proteasome inhibitor, originally isolated from *Streptomyces* bacteria. This compound is a critical research tool for studying the ubiquitin-proteasome pathway, a fundamental regulatory system for protein degradation in eukaryotic cells. It is essential for researchers in biochemistry, cell biology, and pharmacology investigating disease mechanisms, protein turnover, and drug discovery.

Application

• Biomedical Research: A cornerstone reagent for inhibiting the 20S proteasome complex, enabling studies on cell cycle regulation, apoptosis, and signal transduction pathways.
• Mechanistic Studies: Used to elucidate the role of proteasome-dependent protein degradation in neurodegenerative diseases (e.g., Alzheimer's, Parkinson's), cancer, and inflammatory conditions.
• Drug Discovery & Target Validation: Serves as a reference compound and pharmacological tool for screening and developing novel proteasome inhibitors as potential therapeutics.
• Cell Biology: Employed to study the effects of blocked protein degradation on cellular processes, gene expression, and stress responses.
• Biochemical Assay Development: Used as a standard and control in enzymatic assays to measure proteasome activity and inhibition.

Basic Information

Product Name	Lactacystin
CAS No.	133343-34-7
Molecular Formula	C15H24N2O7S
Molecular Weight	376.43 g/mol
Synonyms	Lactacystin; (2S,3R)-3-Hydroxy-2-[(1S)-1-hydroxy-2-methylpropyl]-6-oxo-4-propyl-1-azacyclohexane-4-carbothioic acid S-oxide; Clasto-Lactacystin β-lactone; Proteasome Inhibitor I; Omuralide precursor
EINECS	Contact for details

Quality Control

Our Lactacystin is manufactured under strict quality management systems to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant standards for research-grade biochemicals to guarantee reliable and reproducible experimental results.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Biological Activity (Proteasome Inhibition)	IC50 ≤ 10 µM

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.