Description

(-)-U-50488 Hydrochloride is a potent and selective κ-opioid receptor (KOR) agonist, widely recognized as a key pharmacological research tool. Its high selectivity makes it invaluable for studying KOR-mediated signaling pathways, pain modulation, and neuropsychiatric disorders in preclinical research. This compound is essential for pharmaceutical R&D, academic neuroscience, and biotechnology sectors focused on developing novel analgesics and central nervous system therapeutics.

Application

• Pharmacological Research: A standard reference agonist for studying κ-opioid receptor (KOR) function, signaling, and desensitization.
• Neuroscience Studies: Used in vitro and in vivo models to investigate KOR's role in pain perception, mood regulation, and addiction.
• Drug Discovery & Development: Serves as a critical tool compound for screening, validating, and characterizing new KOR-targeted drug candidates.
• Biochemical Assays: Employed in receptor binding assays, functional cellular assays (e.g., cAMP inhibition), and second messenger studies.
• Analgesic Mechanism Research: Used to explore non-addictive, KOR-mediated pathways for pain relief, distinct from mu-opioid receptors.
• Academic & Institutional Research: A fundamental reagent for university and government lab research into opioid receptor biology and neuropharmacology.

Basic Information

Item	Details
Product Name	(-)-U-50488 Hydrochloride
CAS No.	133162-85-3
Molecular Formula	C18H28ClN2O2 • HCl
Molecular Weight	377.34 g/mol
Synonyms	U-50488 Hydrochloride; (trans)-3,4-Dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]benzeneacetamide monohydrochloride; U-50488H; (-)-U50,488 hydrochloride; (1S,2S)-U-50488 hydrochloride; Kappa opioid receptor agonist U-50488 hydrochloride; CI-977 (related analog); PD-117302 (related analog)
EINECS	Contact for details

Quality Control

Our (-)-U-50488 Hydrochloride is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to rigorous analytical standards, utilizing techniques such as HPLC, NMR, and mass spectrometry for verification. COAs are available upon request for your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment. Keep the container tightly sealed in a cool, dry place after each use to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%
Heavy Metals	≤20 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.