Description

Trapoxin B CAS NO 133155-90-5 is a potent and selective cyclic tetrapeptide known for its irreversible inhibition of histone deacetylases (HDACs), particularly Class I and II HDACs. This compound serves as a critical biochemical tool for epigenetic research, enabling the study of chromatin remodeling, gene expression, and cellular differentiation pathways. It is primarily utilized by researchers and developers in the fields of academic research, pharmaceutical discovery, and biotechnology for probing HDAC function and developing novel therapeutic strategies.

Application

• Epigenetics and Chromatin Research: As a potent HDAC inhibitor, it is used to study the role of histone acetylation in gene regulation, cell cycle, and differentiation.
• Cancer Biology Studies: Employed to investigate the therapeutic potential of HDAC inhibition in various cancer cell lines and animal models.
• Neuroscience Research: Used to explore the role of epigenetic modifications in neuronal development, synaptic plasticity, and neurodegenerative diseases.
• Chemical Biology Probe Development: Serves as a lead compound or a molecular scaffold for designing new chemical probes targeting specific HDAC isoforms.
• Pharmaceutical R&D: Utilized in high-throughput screening assays and target validation studies during the early stages of drug discovery for oncology and neurology.
• Biochemical Assay Standard: Acts as a reference standard in enzymatic assays to measure HDAC activity and evaluate the potency of novel inhibitors.

Basic Information

Product Name	Trapoxin B
CAS No.	133155-90-5
Molecular Formula	C₂₉H₃₅N₅O₆
Molecular Weight	537.62 g/mol
Synonyms	Cyclo[(2S)-2-Amino-8-oxodecanoyl-L-tryptophyl-L-isoleucyl-(2R,5E,9S)-2-amino-10-oxo-8-deceno-yl]; FR901228 (related analog); HDAC Inhibitor IV; Cyclic Tetrapeptide HDAC Inhibitor; [8-Oxo-L-norleucyl-L-tryptophyl-L-isoleucyl-D-prolyl] (lactone); Trapoxin B, from fungal metabolites
EINECS	Contact for details

Quality Control

Our Trapoxin B is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity, MS for identity confirmation, and NMR for structural verification. Certificates of Analysis (COA) detailing all specifications and test results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. Due to its hygroscopic nature, the product should be handled under anhydrous conditions and allowed to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.