Description

Trapoxin A CAS NO 133155-89-2 is a potent and selective cyclic tetrapeptide histone deacetylase (HDAC) inhibitor. This compound is a critical research tool for studying chromatin remodeling, gene expression, and epigenetic regulation in cellular processes. It is primarily utilized by researchers and scientists in the fields of biochemistry, oncology, and epigenetics for mechanistic studies and drug discovery programs.

Application

• Epigenetics Research: As a specific HDAC inhibitor, it is used to investigate the role of histone acetylation in gene silencing and activation.
• Cancer Biology Studies: Employed to explore the effects of HDAC inhibition on cell cycle arrest, differentiation, and apoptosis in various cancer cell lines.
• Neuroscience Research: Used in models to study the epigenetic mechanisms underlying neuronal development, synaptic plasticity, and neurodegenerative diseases.
• Biochemical Assay Development: Serves as a reference standard and positive control in enzymatic assays targeting HDAC activity.
• Drug Discovery & Pharmacology: A key compound for screening and validating new therapeutic agents aimed at modulating HDAC function.
• Cell Signaling Pathways: Utilized to dissect signaling cascades and cellular responses linked to chromatin structure modification.

Basic Information

Product Name	Trapoxin A
CAS No.	133155-89-2
Molecular Formula	C₂₉H₃₅N₃O₆
Molecular Weight	521.61 g/mol
Synonyms	Trapoxin A; Cyclo[(2S)-2-Amino-8-oxodecanoyl-L-tryptophyl-L-isoleucyl-D-pipecolyl]; FR901228 Analog; HDAC Inhibitor I, Trapoxin A; NSC 339821; L-731,735; [Ile-Trp-Pip-Aoda]-Lactam (Aoda = 2-Amino-8-oxodecanoic Acid)
EINECS	Contact for details

Quality Control

Our Trapoxin A is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency for research applications. Each lot undergoes comprehensive analytical testing including HPLC, MS, and NMR for identity and purity verification. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with our stringent specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated under an inert atmosphere. Allow the vial to warm to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%
Biological Activity (HDAC Inhibition)	IC₅₀ ≤ 10 nM

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.