Description

Go 6983 CAS NO 133053-19-7 is a potent and selective cell-permeable protein kinase C (PKC) inhibitor. This compound matters as a critical research tool for elucidating the role of PKC isoforms in cellular signaling pathways, disease mechanisms, and potential therapeutic interventions. It is primarily needed by researchers and scientists in the fields of biochemistry, pharmacology, and oncology for in vitro and in vivo studies.

Application

• Biochemical Research: Used as a selective inhibitor to study the function and regulation of Protein Kinase C (PKC) isoforms, particularly PKCα, β, γ, δ, and ζ.
• Signal Transduction Studies: Essential for investigating PKC-mediated pathways in cell proliferation, differentiation, apoptosis, and tumor promotion.
• Pharmacological Screening: Serves as a reference standard and tool compound in drug discovery programs targeting PKC for conditions like cancer and cardiovascular diseases.
• Neuroscience Research: Applied in studies exploring PKC's role in neuronal plasticity, memory formation, and neurodegenerative disorders.
• Cell Biology Assays: Utilized to modulate PKC activity in cell culture models to understand its impact on specific cellular responses and phenotypes.

Basic Information

Product Name	Go 6983
CAS No.	133053-19-7
Molecular Formula	C₂₆H₂₇N₅O₂
Molecular Weight	441.52 g/mol
Synonyms	Go6983; Go-6983; 3-[1-[3-(Dimethylamino)propyl]-5-methoxy-1H-indol-3-yl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione; 2,5-Pyrrolidinedione, 3-[1-[3-(dimethylamino)propyl]-5-methoxy-1H-indol-3-yl]-4-(1H-indol-3-yl)-1H-; PKC Inhibitor Go 6983; Protein Kinase C Inhibitor Go6983
EINECS	Contact for details

Quality Control

Our Go 6983 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay results, and analytical methods is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the vial to warm to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Solubility	Soluble in DMSO, ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.