Description

Gf109203X is a potent and selective inhibitor of protein kinase C (PKC), a key enzyme family involved in numerous cellular signaling pathways. This high-purity biochemical tool is essential for researchers investigating signal transduction mechanisms in cell biology and pharmacology. It is primarily utilized in life science research, pharmaceutical development, and academic laboratories for studying PKC-mediated processes in areas such as oncology, neuroscience, and immunology.

Application

• Biochemical Research: A critical tool for selectively inhibiting PKC isoforms (particularly PKCα, βI, βII, and γ) in in vitro enzyme assays and cell-based studies to elucidate signaling pathways.
• Pharmaceutical R&D: Used in target validation and lead compound screening to assess the therapeutic potential of modulating PKC activity in diseases like cancer, diabetes, and cardiovascular disorders.
• Neuroscience Studies: Applied in research on synaptic plasticity, neurotransmitter release, and neuronal survival/death mechanisms where PKC plays a regulatory role.
• Immunology Research: Employed to study PKC's function in immune cell activation, cytokine production, and inflammatory responses.
• Cell Biology: Used to probe the role of PKC in cell proliferation, differentiation, apoptosis, and membrane transport processes.

Basic Information

Product Name	Gf109203X
CAS No.	133052-90-1
Molecular Formula	C25H21N3O4
Molecular Weight	427.46 g/mol
Synonyms	Bisindolylmaleimide I; GF 109203X; GF109203X; Go 6850; BIM I; 2-[1-(3-Dimethylaminopropyl)-1H-indol-3-yl]-3-(1H-indol-3-yl)maleimide; Protein Kinase C Inhibitor, GF109203X; PKC Inhibitor GF109203X
EINECS	Contact for details

Quality Control

Our Gf109203X is manufactured under strict quality management systems to ensure batch-to-batch consistency and reliability for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity verification and identity confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting the exact specifications and test results.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	Yellow to orange solid
Identification (HPLC)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Solubility	Soluble in DMSO, DMF; slightly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.