Description

[2-(Trifluoromethyl)-1,3-Thiazol-4-Yl]Methanol CAS NO 133046-47-6 is a high-value trifluoromethyl-substituted thiazole derivative, serving as a critical building block in advanced organic synthesis. Its core value lies in the unique combination of the thiazole heterocycle and the trifluoromethyl group, which are instrumental in modulating the physicochemical and biological properties of target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it is used to develop novel active ingredients with enhanced potency, metabolic stability, and bioavailability.

Application

• Pharmaceutical Intermediate: A key synthon for the development of new drug candidates, particularly in antiviral, anticancer, and anti-inflammatory research programs.
• Agrochemical Synthesis: Used in the creation of advanced pesticides and herbicides, where the trifluoromethyl group often contributes to improved efficacy and environmental profile.
• Material Science Precursor: Employed in the synthesis of specialty chemicals, ligands, and functional materials that require fluorine-containing heterocycles.
• Chemical Biology Probe: Serves as a building block for labeling reagents and molecular probes used in diagnostic and biochemical research.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds for client projects.

Basic Information

Product Name	[2-(Trifluoromethyl)-1,3-Thiazol-4-Yl]Methanol
CAS No.	133046-47-6
Molecular Formula	C5H4F3NOS
Molecular Weight	183.15 g/mol
Synonyms	4-(Hydroxymethyl)-2-(trifluoromethyl)thiazole; 2-(Trifluoromethyl)-4-thiazolemethanol; (2-Trifluoromethyl-1,3-thiazol-4-yl)methanol; 4-Thiazolemethanol, 2-(trifluoromethyl)-; α-(Trifluoromethyl)thiazole-4-methanol
EINECS	Contact for details

Quality Control

Our [2-(Trifluoromethyl)-1,3-Thiazol-4-Yl]Methanol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most critical synthesis steps.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.