Description

Swinholide B CAS NO 132943-68-1 is a potent, naturally occurring macrolide compound originally isolated from marine sponges. This compound serves as a critical research tool in cell biology and pharmacology due to its unique mechanism of action as a potent actin-depolymerizing agent. It is primarily utilized by researchers in the pharmaceutical, biotechnology, and academic sectors for studying cytoskeletal dynamics, cell motility, and as a lead compound in anticancer drug discovery.

Application

• Biomedical Research: Used as a specific biochemical tool to disrupt actin filaments in cell-based assays, enabling the study of cell structure, division, and migration.
• Pharmacology & Drug Discovery: Investigated as a lead compound for the development of novel anticancer therapeutics targeting the actin cytoskeleton.
• Cell Biology Studies: Essential for research focused on understanding the role of actin in cellular processes such as cytokinesis, vesicle trafficking, and signal transduction.
• Biochemical Reagent: Employed in in vitro experiments to study protein-protein interactions involving actin and its associated regulatory proteins.
• Toxicology Research: Used to model and understand the effects of cytoskeletal disruption in various cell types.

Basic Information

Product Name	Swinholide B
CAS No.	132943-68-1
Molecular Formula	C₅₄H₈₄O₁₅
Molecular Weight	997.2 g/mol
Synonyms	Swinholide B; 132943-68-1; Swinholide-B; Swinholide B (marine sponge metabolite); (1S,2S,4S,5S,7S,9S,10S,12S,13S,15S,16S,18S,19S,21S,22S,24S,25S,27S,28S,30S,31S,33S,34S,36S,37S,39S,40S,42S,43S,45S,46S,48S,49S,51S,52S,54S)-2,5,10,13,18,21,26,29,34,37,42,45,50,53-Tetradecaoxapentacyclo[49.3.1.1⁴,⁷.1¹⁹,²².1³⁴,³⁷]pentacontane-3,6,11,14,19,22,27,30,35,38,43,46,51,54-tetradecone
EINECS	Contact for details

Quality Control

Our Swinholide B is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity for research applications. Each lot is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and other critical parameters is provided with every shipment to support your research and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store the product at -20°C or below under an inert atmosphere. The container should be kept in a dry, cool, and well-ventilated area, away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.