Description

Ethanone, 1-(6-Ethoxy-3-Pyridinyl)-2,2,2-Trifluoro- (9Ci) is a high-purity trifluoromethyl ketone derivative with a pyridine core, serving as a critical advanced intermediate in modern synthetic chemistry. Its value lies in enabling the precise construction of complex molecules, particularly in the development of novel active ingredients. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical sectors, where it is used to synthesize new drug candidates and crop protection agents.

Application

• Pharmaceutical Intermediate: A key building block for synthesizing active pharmaceutical ingredients (APIs), particularly in the development of central nervous system (CNS) and anti-infective drugs.
• Agrochemical Synthesis: Used in the research and production of novel herbicides and insecticides, leveraging the trifluoromethyl group for enhanced biological activity and stability.
• Material Science Research: Serves as a precursor for developing specialty polymers and liquid crystals, where the pyridine and ketone functionalities offer unique electronic properties.
• Chemical Biology & Proteomics: Employed as a reactive handle or probe in activity-based protein profiling (ABPP) and the study of enzyme mechanisms.
• Organic Synthesis: A versatile reagent for constructing complex heterocyclic frameworks through cross-coupling and nucleophilic addition reactions.
• Fluorine Chemistry: A valuable source of the trifluoroacetyl moiety for introducing fluorine atoms into target molecules to modulate their lipophilicity and metabolic stability.

Basic Information

Product Name	Ethanone, 1-(6-Ethoxy-3-Pyridinyl)-2,2,2-Trifluoro- (9Ci)
CAS No.	132877-25-9
Molecular Formula	C9H8F3NO2
Molecular Weight	219.16 g/mol
Synonyms	1-(6-Ethoxy-3-pyridinyl)-2,2,2-trifluoroethanone; 2,2,2-Trifluoro-1-(6-ethoxy-3-pyridinyl)ethanone; 6-Ethoxy-3-pyridinyl trifluoromethyl ketone; 1-(6-Ethoxy-3-pyridyl)-2,2,2-trifluoroethanone; 2,2,2-Trifluoro-1-(6-ethoxy-3-pyridinyl)ethan-1-one; Trifluoro(6-ethoxy-3-pyridinyl)methanone; CAS 132877-25-9
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. We employ advanced analytical techniques including HPLC, GC, NMR, and mass spectrometry to verify identity, purity, and impurity profiles. Certificates of Analysis (COA) are available upon request, detailing batch-specific results. Our quality management system is designed to support cGMP requirements for pharmaceutical and advanced intermediate applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.